Efficacy of a respiratory syncytial virus vaccine candidate in a maternal immunization model

Autor: Lurds R. Fernando, Lori McGinnes-Cullen, Lioubov M. Pletneva, Raymonde O. Otoa, Trudy G. Morrison, Marina S. Boukhvalova, Mira C. Patel, Jorge C. G. Blanco
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
G protein
Science
viruses
General Physics and Astronomy
Respiratory Syncytial Virus Infections
Antibodies
Viral
complex mixtures
General Biochemistry
Genetics and Molecular Biology
Virus
Article
03 medical and health sciences
0302 clinical medicine
Virus vaccine
Viral Envelope Proteins
Immunity
medicine
Respiratory Syncytial Virus Vaccines
Animals
Humans
030212 general & internal medicine
Sigmodontinae
Respiratory system
lcsh:Science
Lung
Multidisciplinary
biology
business.industry
virus diseases
General Chemistry
medicine.disease
Virology
3. Good health
Rats
Vaccination
Disease Models
Animal
030104 developmental biology
Bronchiolitis
Respiratory Syncytial Virus
Human
biology.protein
Female
Immunization
lcsh:Q
Antibody
business
Immunity
Maternally-Acquired
Viral Fusion Proteins
Zdroj: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
ISSN: 2041-1723
Popis: Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in infants. Maternal immunization is an option to increase maternal antibody levels and protect infants from infection. Here we assess the efficacy of virus-like particle (VLP) vaccine candidates containing stabilized pre-fusion (pre-F) or post-fusion (post-F) conformations of the RSV F protein and the attachment RSV G protein in a maternal immunization model using cotton rats. VLP vaccines containing RSV F and G proteins strongly boost pre-existing RSV immunity in dams preventing their perinatal drop in immunity. Boosting is stronger for the pre-F VLP than for the post-F VLP or purified subunit F protein vaccines, giving an advantage on mothers’ protection. VLP immunization of dams provides significant protection to pups from RSV challenge and reduced pulmonary inflammation. Collectively, our results show that a VLP vaccine with RSV F and G proteins is safe and effective for maternal and adult vaccination.
RSV infection is a major cause of bronchiolitis in infants and maternal vaccination is a potential preventive option. Here, Blanco et al. show efficacy of a Newcastle disease virus-based virus-like particle vaccine candidate in naive and pre-exposed cotton rat dams and their offspring.
Databáze: OpenAIRE
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