Noninvasive Retinal Markers in Diabetic Retinopathy:Advancing from Bench towards Bedside
| Autor: | Kerstin Soelberg, Ulrik Frydkjaer-Olsen, Søren Leer Blindbæk, Rebecca Broe, Anders Højslet Vestergaard, Jakob Grauslund, Kristian Lundberg, Thomas Lee Torp, Majbrit Lind, Christina Døfler Poulsen, Malin Lundberg Rasmussen, Jimmi Wied, Tunde Peto, Anna Stage Vergmann |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Fundus Oculi Denmark Endocrinology Diabetes and Metabolism Treatment outcome Population Øjensygdomme 030209 endocrinology & metabolism Oftamologi Review Article Review Light Coagulation lcsh:Diseases of the endocrine glands. Clinical endocrinology Macular Edema 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology SDG 3 - Good Health and Well-being Diabetes mellitus Ophthalmology Journal Article Humans Medicine In patient Oximetry education education.field_of_study lcsh:RC648-665 Diabetic Retinopathy business.industry Diabetes Retinal Vessels Retinal Diabetic retinopathy medicine.disease University hospital Treatment Outcome chemistry 030221 ophthalmology & optometry business Diabetiske øjensygdomme |
| Zdroj: | Blindbæk, S L, Torp, T L, Lundberg, K, Soelberg, K, Vergmann, A S, Poulsen, C D, Frydkjær-Olsen, U, Broe, R, Rasmussen, M L, Wied, J, Lind, M, Vestergaard, A H, Peto, T & Grauslund, J 2017, ' Noninvasive Retinal Markers in Diabetic Retinopathy : Advancing from Bench towards Bedside ', Journal of Diabetes Research, vol. 2017, 2562759 . https://doi.org/10.1155/2017/2562759 Blindbæk, S L, Torp, T L, Lundberg, K, Soelberg, K, Vergmann, A S, Poulsen, C D, Frydkjaer-Olsen, U, Broe, R, Rasmussen, M L, Wied, J, Lind, M, Vestergaard, A H, Peto, T & Grauslund, J 2017, ' Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside ', Journal of Diabetes Research, vol. 2017, pp. 2562759 . https://doi.org/10.1155/2017/2562759 Journal of Diabetes Research Journal of Diabetes Research, Vol 2017 (2017) |
| DOI: | 10.1155/2017/2562759 |
| Popis: | The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- and macrovascular dysfunction in diabetes. Likewise, the retinal metabolism can be evaluated by retinal oximetry, and higher retinal venular oxygen saturation has been demonstrated in patients with diabetic retinopathy. So far, most studies have been cross-sectional, but these can only disclose associations and are not able to separate cause from effect or to establish the predictive value of retinal vascular dysfunction with respect to long-term complications. Likewise, retinal markers have not been investigated as markers of treatment outcome in patients with proliferative diabetic retinopathy and diabetic macular edema. The Department of Ophthalmology at Odense University Hospital, Denmark, has a strong tradition of studying the retinal microvasculature in diabetic retinopathy. In the present paper, we demonstrate the importance of the retinal vasculature not only as predictors of long-term microvasculopathy but also as markers of treatment outcome in sight-threatening diabetic retinopathy in well-established population-based cohorts of patients with diabetes. |
| Databáze: | OpenAIRE |
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