Location-dependent synaptic plasticity rules by dendritic spine cooperativity
| Autor: | Jens P. Weber, Bertalan K. Andrasfalvy, Marina Polito, Judit K. Makara, Balázs Ujfalussy, Ádám Magó |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Dendritic spine Patch-Clamp Techniques genetic structures Science Dendritic Spines Long-Term Potentiation General Physics and Astronomy Nonsynaptic plasticity Glutamic Acid Biology Hippocampus Receptors N-Methyl-D-Aspartate General Biochemistry Genetics and Molecular Biology Article Tissue Culture Techniques 03 medical and health sciences 0302 clinical medicine Synaptic augmentation Animals Calcium Signaling Rats Wistar Multidisciplinary Pyramidal Cells Sodium Excitatory Postsynaptic Potentials Long-term potentiation General Chemistry Anatomy Microtomy Dendritic filopodia Rats 030104 developmental biology Synaptic fatigue Synaptic plasticity Synapses NMDA receptor Calcium Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
| ISSN: | 2041-1723 |
| Popis: | Nonlinear interactions between coactive synapses enable neurons to discriminate between spatiotemporal patterns of inputs. Using patterned postsynaptic stimulation by two-photon glutamate uncaging, here we investigate the sensitivity of synaptic Ca2+ signalling and long-term plasticity in individual spines to coincident activity of nearby synapses. We find a proximodistally increasing gradient of nonlinear NMDA receptor (NMDAR)-mediated amplification of spine Ca2+ signals by a few neighbouring coactive synapses along individual perisomatic dendrites. This synaptic cooperativity does not require dendritic spikes, but is correlated with dendritic Na+ spike propagation strength. Furthermore, we show that repetitive synchronous subthreshold activation of small spine clusters produces input specific, NMDAR-dependent cooperative long-term potentiation at distal but not proximal dendritic locations. The sensitive synaptic cooperativity at distal dendritic compartments shown here may promote the formation of functional synaptic clusters, which in turn can facilitate active dendritic processing and storage of information encoded in spatiotemporal synaptic activity patterns. Inputs to functionally related synapses have been suggested to show cooperative summation, although the rules governing these interactions are unclear. Here, Weber et al. uncover non-linear interactions dependent on NMDAR signalling that vary across the proximal-distal axis of individual dendrites. |
| Databáze: | OpenAIRE |
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