Tumor Sink Effect in 68Ga-PSMA-11 PET: Myth or Reality?
| Autor: | Michael S Hofman, Johannes Czernin, Clemens Kratochwil, David Elashoff, Rouzbeh Esfandiari, Isabel Rauscher, Bjoern H. Menze, Ken Herrmann, Jeremie Calais, Hui Wang, Manuel Weber, Farid Yagubbayli, Wolfgang P. Fendler, Matthias Eiber, Ebrahim S. Delpassand, Andrei Gafita, Andrew Robertson, Wesley R Armstrong, Kathleen Nguyen, Tristan Grogan, Fernando Navarro, Raphael Zaum |
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| Přispěvatelé: | University of Zurich |
| Rok vydání: | 2022 |
| Předmět: |
Male
Urologic Diseases medicine.medical_specialty Biodistribution Life on Land Clinical Sciences Urology Tumor burden 610 Medicine & health Spleen Gallium Radioisotopes urologic and male genital diseases Nuclear Medicine and imaging 68Ga-PSMA-11 Prostate cancer Interquartile range Positron Emission Tomography Computed Tomography medicine PSMA Humans Radiology Nuclear Medicine and imaging Tissue Distribution Clinical Investigation Tumor Load Gallium Isotopes Edetic Acid Retrospective Studies Cancer tumor sink effect business.industry Prostatic Neoplasms medicine.disease prostate cancer radioligand therapy Nuclear Medicine & Medical Imaging medicine.anatomical_structure PET Ga-PSMA Radionuclide therapy Biomedical Imaging Radiology business Digestive Diseases 11493 Department of Quantitative Biomedicine |
| Zdroj: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol 63, iss 2 J Nucl Med |
| Popis: | We aimed to systematically determine the impact of tumor burden on (68)Ga-prostate-specific membrane antigen-11 ((68)Ga-PSMA) PET biodistribution by the use of quantitative measurements. Methods: This international multicenter, retrospective analysis included 406 men with prostate cancer who underwent (68)Ga-PSMA PET/CT. Of these, 356 had positive findings and were stratified by quintiles into a very low (quintile 1, ≤25 cm(3)), low (quintile 2, 25–189 cm(3)), moderate (quintile 3, 189–532 cm(3)), high (quintile 4, 532–1,355 cm(3)), or very high (quintile 5, ≥1,355 cm(3)) total PSMA-positive tumor volume (PSMA-VOL). PSMA-VOL was obtained by semiautomatic segmentation of total tumor lesions using qPSMA software. Fifty prostate cancer patients with no PSMA-positive lesions (negative scan) served as a control group. Normal organs, which included salivary glands, liver, spleen, and kidneys, were semiautomatically segmented using (68)Ga-PSMA PET images, and SUV(mean) was obtained. Correlations between the SUV(mean) of normal organs and PSMA-VOL as continuous and categoric variables by quintiles were evaluated. Results: The median PSMA-VOL was 302 cm(3) (interquartile range [IQR], 47–1,076 cm(3)). The median SUV(mean) of salivary glands, kidneys, liver, and spleen was 10.0 (IQR, 7.7–11.8), 26.0 (IQR, 20.0–33.4), 3.7 (IQR, 3.0–4.7), and 5.3 (IQR, 4.0–7.2), respectively. PSMA-VOL showed a moderate negative correlation with the SUV(mean) of the salivary glands (r = −0.44, P |
| Databáze: | OpenAIRE |
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