Meta-Analysis of Vitamin D Receptor Polymorphisms and Type 1 Diabetes: A HuGE Review of Genetic Association Studies
| Autor: | Victoria L. Magnuson, Jennifer J. Schiller, Yan Wu, Xujing Wang, Sun-Wei Guo, Soumitra Ghosh |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Epidemiology Bioinformatics Calcitriol receptor Risk Factors Polymorphism (computer science) Internal medicine medicine Vitamin D and neurology Humans Genetic Predisposition to Disease Genetic association Type 1 diabetes Polymorphism Genetic business.industry Odds ratio medicine.disease Diabetes Mellitus Type 1 Genetics Population Endocrinology Case-Control Studies Data Interpretation Statistical Meta-analysis Receptors Calcitriol business |
| Zdroj: | American Journal of Epidemiology. 164:711-724 |
| ISSN: | 1476-6256 0002-9262 |
| DOI: | 10.1093/aje/kwj278 |
| Popis: | Several polymorphisms in the vitamin D receptor (VDR ) gene have been reported to be associated with the risk of developing type 1 diabetes, yet published findings have been conflicting. In this study, the authors attempted to evaluate the evidence regarding the association. They searched all relevant reports from original papers published from 1997 to December 2005. Predefined criteria were used to identify 1) case-control association studies examining the Fok I (11 studies), Bsm I (13 studies), Apa I (9 studies), and Taq I (7 studies) polymorphisms and 2) a few family-transmission studies with analysis of these four polymorphisms. In random-effects modeling, the 95% confidence intervals of the summary odds ratios for all four polymorphisms included 1, indicating no effect. Except for Fok I, no heterogeneity was found. The 95% confidence intervals of the transmission proportions all included 0.5, indicating no effect. Thus, the authors found no evidence for an association between VDR gene polymorphisms and type 1 diabetes risk in either case-control studies or family-transmission studies. In fact, a reanalysis of previously published data (McDermott et al., Diabetologia 1997;40:971–5) indicated no evidence of an association as reported. association; diabetes mellitus, type 1; epidemiology; genetics; meta-analysis; polymorphism, genetic; receptors, calcitriol; VDR |
| Databáze: | OpenAIRE |
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