Relationship between temperature variability and brain injury on magnetic resonance imaging in cooled newborn infants after perinatal asphyxia

Autor: R Gunny, Ulrike Held, Barbara Brotschi, Beatrice Latal, Cornelia Hagmann, C Rethmann
Přispěvatelé: University of Zurich, Brotschi, B
Rok vydání: 2016
Předmět:
Time Factors
Resuscitation
Encephalopathy
610 Medicine & health
Gestational Age
Severity of Illness Index
Body Temperature
03 medical and health sciences
0302 clinical medicine
Hypothermia
Induced
Risk Factors
Intensive Care Units
Neonatal
Severity of illness
medicine
Humans
2735 Pediatrics
Perinatology and Child Health
030212 general & internal medicine
Prospective Studies
Registries
Prospective cohort study
Asphyxia
Asphyxia Neonatorum
medicine.diagnostic_test
business.industry
Infant
Newborn
Obstetrics and Gynecology
2729 Obstetrics and Gynecology
Magnetic resonance imaging
Odds ratio
10027 Clinic for Neonatology
medicine.disease
Magnetic Resonance Imaging
Perinatal asphyxia
10036 Medical Clinic
Anesthesia
Pediatrics
Perinatology and Child Health
Hypoxia-Ischemia
Brain
10029 Clinic and Policlinic for Internal Medicine
medicine.symptom
business
030217 neurology & neurosurgery
Zdroj: Journal of perinatology : official journal of the California Perinatal Association. 37(9)
ISSN: 1476-5543
Popis: The objective of the study was whether temperature management during therapeutic hypothermia correlates with the severity of brain injury assessed on magnetic resonance imaging in term infants with hypoxic-ischemic encephalopathy. Prospectively collected register data from the National Asphyxia and Cooling Register of Switzerland were analyzed. Fifty-five newborn infants were cooled for 72 h with a target temperature range of 33 to 34 °C. Individual temperature variability (odds ratio (OR) 40.17 (95% confidence interval (CI) 1.37 to 1037.67)) and percentage of temperatures within the target range (OR 0.95 (95% CI 0.90 to 0.98)) were associated with the severity of brain injury seen on magnetic resonance imaging (MRI). Neither the percentage of measured temperatures above (OR 1.08 (95% CI 0.96 to 1.21)) nor below (OR 0.99 (95% CI 0.92 to 1.07) the target range was associated with the severity of brain injury seen on MRI. In a national perinatal asphyxia cohort, temperature variability and percentage of temperatures within the target temperature range were associated with the severity of brain injury.
Databáze: OpenAIRE
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