Pulsatile LH-RH administration induces puberty in hypogonadotropic GH-deficient patients
| Autor: | Mihoko Kodama, Noritaka Iwatani, Teruhisa Miike |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.drug_class Endocrinology Diabetes and Metabolism Pulsatile flow Gonadotropin-releasing hormone Hypothalamic disease Chorionic Gonadotropin Gonadotropin-Releasing Hormone Endocrinology Hypogonadotropic hypogonadism Internal medicine medicine Humans Testosterone Child Puberty Delayed business.industry Hypogonadism medicine.disease Treatment Outcome Growth Hormone Gonadotropin business Spermatogenesis Gonadotropins Hormone |
| Zdroj: | Endocrine journal. 40(2) |
| ISSN: | 0918-8959 |
| Popis: | Three growth hormone (GH) deficient males with hypogonadotropic hypogonadism were treated with pulsatile luteinizing hormone-releasing hormone (LH-RH) administration. In two of them, the GH deficiency was idiopathic, but in the other it was secondary, caused by suprasellar germinoma. In response to LH-RH therapy, the serum testosterone (T), testicular volume, and body height increased in all three patients, and normal serum T levels and spermatogenesis were achieved in two patients. Gonadotropin responses to an LH-RH test preceding therapy did not seem to be an accurate predictor of the success of LH-RH therapy. We conclude that GH-deficient patients with hypogonadotropic hypogonadism can be expected to achieve normal pubertal development and spermatogenesis with pulsatile LH-RH administration. |
| Databáze: | OpenAIRE |
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