Acute Effects of Graduated Elastic Compression Stockings in Patients with Symptomatic Varicose Veins: A Randomised Double Blind Placebo Controlled Trial
| Autor: | Konstantinos M. Nikolakopoulos, Stavros K. Kakkos, Anastasia Kouri, Marios Timpilis, Chrysanthi P. Papageorgopoulou, Panayiotis Patrinos, George Lampropoulos, Ioannis Ntouvas, Spyros Papadoulas, Ioannis A. Tsolakis |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Visual analogue scale Placebo-controlled study Pain 030204 cardiovascular system & hematology Placebo law.invention Placebos Varicose Veins Double blind 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial law Varicose veins medicine Edema Humans Pain Management 030212 general & internal medicine Aged Pain Measurement Leg business.industry Middle Aged Treatment Outcome medicine.anatomical_structure Anesthesia Number needed to treat Physical therapy Female Surgery medicine.symptom Ankle Cardiology and Cardiovascular Medicine business Stockings Compression |
| Zdroj: | European Journal of Vascular and Endovascular Surgery. 55:118-125 |
| ISSN: | 1078-5884 |
| DOI: | 10.1016/j.ejvs.2017.10.004 |
| Popis: | Objectives To investigate the effectiveness of graduated elastic compression stockings (GECS) below the knee in improving symptoms in patients with varicose veins in the absence of high quality evidence. Methods This was a randomised double blind placebo controlled trial. Thirty patients with no experience of elastic stockings, presenting with primary varicose veins causing calf pain or aching were randomised to a GECS (18-21 mmHg at the ankle level, n=15) or a placebo stocking (0 mmHg, n=15). Pain or aching of the index leg after 1 week was the primary outcome measure. In patients with bilateral varicose veins the leg with the most severe pain/aching was considered. Other defined symptoms were secondary outcome measures. All symptoms were scored on a visual analogue scale (VAS). Results The two study groups were well balanced at baseline. At the completion of the study after 1 week, GECS were more effective than placebo stockings in reducing pain or aching (VAS score 1.7±3.0 vs. 4.5±2.8 for placebo, p=.02), while non-significant trends were observed for some of the remaining symptoms of the index leg, including feeling of swelling (VAS score 0.9±1.9 vs. 3.3±3.5 for placebo), paraesthesiae (VAS score 0.2±0.6 vs. 2.1±3.1 for placebo), and the number of symptoms other than pain or aching (1.3±1.1 vs. 2.8±1.7 for placebo). Number needed to treat (95% CI) for a 50% or complete improvement of pain or aching in the index leg was 2 (95% CI 1.2–5.5) and 2 (95% CI 1.2–5.3), respectively. Mean daily use of the placebo stockings and GECS was 8.0 hours and 10.2 hours, respectively (p=.13). Conclusions Among patients with varicose veins, GECS seem effective in ameliorating symptoms, particularly pain or aching, compared with placebo stockings after 1 week of use. Long-term studies are justified. |
| Databáze: | OpenAIRE |
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