Inflammasomes and SARS-CoV-2 Infection
| Autor: | Juha Kaivola, Tuula Anneli Nyman, Sampsa Matikainen |
|---|---|
| Přispěvatelé: | HUS Inflammation Center, Reumatologian yksikkö, TRIMM - Translational Immunology Research Program, Department of Medicine, Clinicum |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
COVID-19 Vaccines
Interleukin-1beta Review Adaptive Immunity Microbiology NLRP3 INFLAMMASOME MECHANISMS ACTIVATION 03 medical and health sciences 0302 clinical medicine Virology Pyroptosis Humans inflammasomes innate immunity 030304 developmental biology Inflammation 11832 Microbiology and virology 0303 health sciences ROLES Cell Death SARS-CoV-2 Interleukin-18 COVID-19 AIM2 INFLAMMASOME QR1-502 Immunity Innate cytokines 3. Good health Neoplasm Proteins APOPTOSIS Infectious Diseases IL-1-BETA 3121 General medicine internal medicine and other clinical medicine VIRUS mRNA Vaccines Cytokine Release Syndrome 030215 immunology |
| Zdroj: | Viruses Viruses, Vol 13, Iss 2513, p 2513 (2021) |
| ISSN: | 1999-4915 |
| Popis: | SARS-CoV-2 is a new type of coronavirus that has caused worldwide pandemic. The disease induced by SARS-CoV-2 is called COVID-19. A majority of people with COVID-19 have relatively mild respiratory symptoms. However, a small percentage of COVID-19 patients develop a severe disease where multiple organs are affected. These severe forms of SARS-CoV-2 infections are associated with excessive production of pro-inflammatory cytokines, so called "cytokine storm". Inflammasomes, which are protein complexes of the innate immune system orchestrate development of local and systemic inflammation during virus infection. Recent data suggest involvement of inflammasomes in severe COVID-19. Activation of inflammasome exerts two major effects: it activates caspase-1-mediated processing and secretion of pro-inflammatory cytokines IL-1 beta and IL-18, and induces inflammatory cell death, pyroptosis, via protein called gasdermin D. Here, we provide comprehensive review of current understanding of the activation and possible functions of different inflammasome structures during SARS-CoV-2 infection and compare that to response caused by influenza A virus. We also discuss how novel SARS-CoV-2 mRNA vaccines activate innate immune response, which is a prerequisite for the activation of protective adaptive immune response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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