THE PERITONEUM AS A NOVEL OXYGENATION ORGAN
| Autor: | Tadaaki Maehara, Noriyuki Matsutani, Masayuki Ishihara, Yuichi Ozeki, Bonpei Takase, Yashiro Nogami |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Erythrocytes medicine.medical_treatment Hemodynamics Critical Care and Intensive Care Medicine Models Biological Artificial lung Peritoneal cavity Dogs Oxygen Consumption Peritoneum Respiration medicine Animals Peritoneal Cavity Saline Pulmonary Gas Exchange business.industry Oxygenation Carbon Dioxide Respiration Disorders Surgery Oxygen Perfusion medicine.anatomical_structure Emergency Medicine business |
| Zdroj: | Shock. 30:250-253 |
| ISSN: | 1073-2322 |
| DOI: | 10.1097/shk.0b013e318162be0a |
| Popis: | Supplemental oxygenation is important in reversible pulmonary failure. To determine whether the peritoneal cavity can be used as a source of "extrapulmonary respiration," we perfused the peritoneal cavity with oxygenated red blood cells (RBCs) and saline, and measured the amount of oxygenation delivered through the peritoneum of dogs under controlled ventilation. Inflow and outflow catheters were placed in the peritoneal cavity and connected to a perfusion circuit. We investigated the safety of this procedure by examining the relationship between intraperitoneal infusion volume and hemodynamic changes in dogs that underwent peritoneal perfusion with oxygenated RBC (n = 6) and with oxygenated saline (n = 6). The controls comprised dogs that underwent a sham operation (n = 6). We found that an intraperitoneal infusion of less than 1,250 mL was hemodynamically safe. Oxygenation levels (PaO2) increased most obviously with an intraperitoneal infusion of oxygenated RBC. The peritoneum can potentially serve as an "artificial lung" in critically ill patients. |
| Databáze: | OpenAIRE |
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