Preliminary characterization of the pituitary melanocyte stimulating hormones of several vertebrate species
| Autor: | Menachem Shapiro, William M. Mitchell, David N. Orth, Wendell E. Nicholson, Grant W. Liddle, Donald P. Island |
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| Rok vydání: | 1972 |
| Předmět: |
endocrine system
medicine.medical_specialty Pituitary gland animal structures Melanocyte-stimulating hormone Chemical Phenomena Swine Guinea Pigs Radioimmunoassay Flounder Melanocyte Guinea pig Mice Endocrinology Adrenocorticotropic Hormone Species Specificity Internal medicine Iodine Isotopes medicine Bioassay Animals Amino Acid Sequence Melanocyte-Stimulating Hormones Rana catesbeiana integumentary system biology Fishes Reptiles biology.organism_classification Rats Chemistry medicine.anatomical_structure Pituitary Gland Chromatography Gel Cattle Rabbits Anura Chickens hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Endocrinology. 90(1) |
| ISSN: | 0013-7227 |
| Popis: | A survey of pituitaries of several vertebrate species was carried out in an effort to determine whether they contained melanocyte stimulating hormones and, if so, whether they were identical with those which have previously been structurally characterized. All ten of the species studied possessed biologic melanocyte stimulating substances. In only two species (pig and beef) was it possible to account for a majority of the biologic activity in terms of known hormones, using a combination of bioassays for MSH and ACTH and radioimmunoassays for α-MSH, β-MSH and ACTH. In eight species (flounder, frog, iguana, chicken, guinea pig, mouse, rat and rabbit) there was an excess of biologic MSH activity that could not be accounted for by a summation of ACTH, α-MSH, and β- MSH. It is concluded that, in these species, the structures of the major melanocyte stimulating hormones are different from any that have been characterized previously. (Endocrinology 90: 249, 1972) |
| Databáze: | OpenAIRE |
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