Rac1 and PAK1 are upstream of IKK-ε and TBK-1 in the viral activation of interferon regulatory factor-3
| Autor: | Walter J. Wurzer, Stephan Ludwig, Stephan Pleschka, Christian Kardinal, Oliver Planz, Christoph von Eichel-Streiber, Christina Ehrhardt, Thorsten Wolff |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
rac1 GTP-Binding Protein
Transcription Genetic Biophysics IκB kinase Protein Serine-Threonine Kinases Signal transduction Biology Virus Replication Biochemistry Cell Line Dogs PAK1 Structural Biology Interferon Genetics medicine Animals Humans Phosphorylation Promoter Regions Genetic p21-activated kinases Molecular Biology RNA Double-Stranded Kinase Rho GTPase I-Kappa-B Kinase Nuclear Proteins Interferon-beta Cell Biology CREB-Binding Protein I-kappa B Kinase DNA-Binding Proteins Enzyme Activation p21-Activated Kinases Influenza A virus Viral infection Anti-viral response Trans-Activators Cancer research Interferon Regulatory Factor-3 Transcription factor Dimerization Transcription Factors Interferon regulatory factors medicine.drug |
| Zdroj: | FEBS Letters. 567:230-238 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2004.04.069 |
| Popis: | The anti-viral type I interferon (IFN) response is initiated by the immediate induction of IFN beta, which is mainly controlled by the IFN-regulatory factor-3 (IRF-3). The signaling pathways mediating viral IRF-3 activation are only poorly defined. We show that the Rho GTPase Rac1 is activated upon virus infection and controls IRF-3 phosphorylation and activity. Inhibition of Rac1 leads to reduced IFN beta promoter activity and to enhanced virus production. As a downstream mediator of Rac signaling towards IRF-3, we have identified the kinase p21-activated kinase (PAK1). Furthermore, both Rac1 and PAK1 regulate the recently described IRF-3 activators, I kappa B kinase- and TANK-binding kinase-1, establishing a first canonical virus-induced IRF-3 activating pathway. |
| Databáze: | OpenAIRE |
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