Laboratory Parameters of Hemostasis, Adhesion Molecules, and Inflammation in Type 2 Diabetes Mellitus: Correlation with Glycemic Control
| Autor: | Rossella Cimino, Salvatore A. Pullano, Eleonora Palella, Daniela Foti, Elio Gulletta, Antonino S. Fiorillo, Antonio Brunetti, Marta Greco |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male endocrine system diseases type 2 diabetes mellitus Health Toxicology and Mutagenesis lcsh:Medicine 030204 cardiovascular system & hematology Gastroenterology Cohort Studies chemistry.chemical_compound 0302 clinical medicine adhesion molecules medicine.diagnostic_test Cell adhesion molecule Middle Aged Intercellular Adhesion Molecule-1 P-Selectin Cardiovascular Diseases Female E-Selectin Selectin Partial thromboplastin time Adult medicine.medical_specialty Vascular Cell Adhesion Molecule-1 030209 endocrinology & metabolism Article 03 medical and health sciences Internal medicine Plasminogen Activator Inhibitor 1 medicine Humans prothrombotic risk Glycemic Prothrombin time Glycated Hemoglobin business.industry lcsh:R Public Health Environmental and Occupational Health nutritional and metabolic diseases chemistry Diabetes Mellitus Type 2 Glycemic Index inflammation Hemostasis hemostasis Glycated hemoglobin business Cell Adhesion Molecules Biomarkers |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 17 Issue 1 International Journal of Environmental Research and Public Health, Vol 17, Iss 1, p 300 (2020) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph17010300 |
| Popis: | Background: Type 2 diabetes mellitus (T2DM) is characterized by a prothrombotic state, predisposing to vascular complications. Some related markers, linking thrombophilia to hemostasis and inflammation, however, have been poorly explored in relation to patients&rsquo glycemia. We therefore investigated the association of laboratory hemostatic parameters, circulating adhesion molecules (ADMs), white blood cell (WBC) count, and neutrophil/lymphocyte ratio (NLR) with T2DM and glycemic control. Research design: In this study, 82 subjects, grouped into T2DM patients (n = 41) and healthy individuals (n = 41) were enrolled. To evaluate glycemic control, the T2DM cohort was expanded to 133 patients and sub-classified according to glycated hemoglobin (HbA1c) < 7% and &ge 7% (n = 58 and n = 75, respectively). We assessed glycemia, HbA1c, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, plasminogen activator inhibitor-1 (PAI-1), platelet and leukocyte parameters, vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and selectins (E-, P-, L-). Results: PT % activity, PAI-1, VCAM-1, WBC, and neutrophil counts were significantly higher in T2DM patients than in healthy subjects. Poor glycemic control (HbA1c &ge 7%) was correlated with increased PT activity (p = 0.015), and higher levels of E-selectin (p = 0.009), P-selectin (p = 0.012), and NLR (p = 0.019). Conclusions: Both T2DM and poor glycemic control affect some parameters of hemostasis, inflammation, and adhesion molecules. Further studies are needed to establish their clinical utility as adjuvant markers for cardio-vascular risk in T2DM patients. |
| Databáze: | OpenAIRE |
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