Helicobacter pylori eradication using one-week low-dose lansoprazole plus amoxycillin and either clarithromycin or azithromycin
| Autor: | Antonio Tursi, Giovanni Gasbarrini, Massimo Montalto, Alfredo Papa, G Veneto, Lucio Cuoco, Giovanni Cammarota, Giuseppe Fedeli |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Spirillaceae Lansoprazole Rapid urease test Penicillins Azithromycin Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles Drug Administration Schedule Helicobacter Infections Clarithromycin Internal medicine medicine Humans Pharmacology (medical) Prospective Studies Enzyme Inhibitors Aged Antibacterial agent Dose-Response Relationship Drug Helicobacter pylori Hepatology biology business.industry Amoxicillin Proton Pump Inhibitors Middle Aged biology.organism_classification Anti-Bacterial Agents Surgery Drug Therapy Combination Female business Omeprazole medicine.drug |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 10:997-1000 |
| ISSN: | 0269-2813 |
| DOI: | 10.1046/j.1365-2036.1996.d01-533.x |
| Popis: | Aim : To evaluate and compare two 1-week low-dose triple therapies based on lansoprazole, amoxycillin and a macrolide in eradicating Helicobacter pylori. Methods : Seventy consecutive patients, suffering from dyspeptic symptoms with H. pylori infection, were randomly allocated to one of two treatment groups : (A) (LAC ; n = 35) lansoprazole 30 mg once daily, amoxycillin 1000 mg b.d., clarithromycin 250 mg b.d., all for 7 days ; and (B) (LAA ; n = 35) lansoprazole 30 mg once daily and amoxycillin 1000 mg b.d., both for 7 days, plus azithromycin 500 mg once daily for only 3 days. The H. pylori status was evaluated by means of histology and rapid urease test at entry and 8 weeks after treatment. Results : Three patients did not complete the treatment : one in the LAC group was withdrawn owing to severe side-effects ; two patients in the LAA group stopped the treatment prematurely. H. pylori eradication was obtained in 28 of 34 (82% ; 95% CI = 66-93%) patients in the LAC group and in 20 of 33 (61% ; 95% CI = 42-77%) patients in the LAA group. The difference is significant (P < 0.029). On intention-to-treat analysis, the rates of eradication were (28 of 35 patients, 80% in the LAC group and 20 of 35 patients, 57% in the LAA group. Side-effects occurred in nine (26%) and six (18%) patients in the LAC and LAA groups, respectively. Conclusions : Low-dose lansoprazole plus amoxycillin and clarithromycin is more effective than low-dose lansoprazole plus amoxycillin and azithromycin, but it gave a greater incidence of side-effects. |
| Databáze: | OpenAIRE |
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