Lobaplatin promotes 125I-induced apoptosis and inhibition of proliferation in hepatocellular carcinoma by upregulating PERK-eIF2α-ATF4-CHOP pathway

Autor: Yuliang Li, Wujie Wang, Dong Li, Yi-Biao Wang, Yongzheng Wang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Cancer Research
Carcinoma
Hepatocellular
Combination therapy
Organoplatinum Compounds
Immunology
Eukaryotic Initiation Factor-2
Down-Regulation
Mice
Nude
Apoptosis
CHOP
Article
Iodine Radioisotopes
03 medical and health sciences
Cellular and Molecular Neuroscience
eIF-2 Kinase
0302 clinical medicine
Downregulation and upregulation
medicine
Carcinoma
Chemotherapy
Animals
Humans
lcsh:QH573-671
Cell Proliferation
Mice
Inbred BALB C
Radiotherapy
Chemistry
lcsh:Cytology
ATF4
Liver Neoplasms
Cell Biology
Hep G2 Cells
medicine.disease
Activating Transcription Factor 4
Xenograft Model Antitumor Assays
Up-Regulation
Lobaplatin
030104 developmental biology
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Cancer research
Liver cancer
Cyclobutanes
Transcription Factor CHOP
Signal Transduction
Zdroj: Cell Death and Disease, Vol 10, Iss 10, Pp 1-10 (2019)
Cell Death & Disease
ISSN: 2041-4889
Popis: We investigated the mechanism underlying the effect of a combination treatment of 125I radioactive seed implantation and lobaplatin (LBP) in hepatocellular carcinoma. The effects of administration of HCC cells and subcutaneous tumor model of mice with different doses of 125I or a sensitizing concentration of LBP alone, or in combination, on cellular apoptosis and proliferation were analyzed and it was confirmed that LBP promotes 125I-induced apoptosis and inhibition of proliferation of HCC. Furthermore, isobaric tag for relative and absolute quantification labeling analyses suggested that 125I promoted the apoptosis and inhibition of proliferation of HCC cells by upregulating the expression of PERK-eIF2α-ATF4-CHOP pathway, a well-known apoptosis-related pathway. Moreover, LBP was found to boost the 125I-induced upregulation of this pathway and increase the apoptosis. Our data indicate that LBP promotes the apoptotic and anti-proliferative effects of 125I and provide a firm foundation for better clinical application of this combination therapy.
Databáze: OpenAIRE
Externí odkaz: