Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography

Autor:	E.Ya. Rogozinskaya, M. G. Lyapina
Rok vydání:	2017
Předmět:	Male 0301 basic medicine animal structures Arginine medicine.drug_class His-Phe-Arg-Trp-Pro-Gly-Pro Pharmacology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Adrenocorticotropic Hormone medicine Selank Animals Potency Amino Acid Sequence Blood Coagulation Oligopeptide integumentary system medicine.diagnostic_test Chemistry Anticoagulant Thr-Lys-Pro-Arg-Pro-Gly-Pro Anticoagulants General Medicine Peptide Fragments Thromboelastography Rats Thrombelastography 030104 developmental biology embryonic structures Oligopeptides medicine.drug
Zdroj:	Bulletin of Experimental Biology and Medicine. 164:170-172
ISSN:	1573-8221 0007-4888
Popis:	Thromboelastography revealed anticoagulant effects of 3 glyproline oligopeptides (in various concentrations): His-Phe-Arg-Trp-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), and Pro-Gly-Pro. The parameters R, K, MA, S, TMA, and J changed to hypocoagulation direction in comparison to the control. At this, Selank demonstrated the maximal anticoagulation potency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17c2703759da92d9c7afca16bd6a167 https://doi.org/10.1007/s10517-017-3950-4 Zobrazit plný text záznamu Full text from SpringerLink