The acute and residual effects of escalating, analgesic-range doses of ketamine on driving performance: A simulator study
| Autor: | Amie C. Hayley, Yahya Shehabi, Brook Shiferaw, Luke A. Downey, Con Stough, Michael Keane, Maja Green, Panagiota Kostakis |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Automobile Driving Analgesic Poison control 03 medical and health sciences Young Adult 0302 clinical medicine Bolus (medicine) medicine Humans Ketamine Computer Simulation Biological Psychiatry Whole blood Pharmacology Anesthetics Dissociative Dose-Response Relationship Drug business.industry Driving simulator Ketamine hydrochloride Psychotomimetic 030227 psychiatry Anesthesia Female business 030217 neurology & neurosurgery Psychomotor Performance medicine.drug |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 86 |
| ISSN: | 1878-4216 |
| Popis: | Ketamine hydrochloride elicits potent psychotomimetic and neurobehavioural effects which make it incompatible with driving; however, the direct effect on driving performance is yet to be assessed. Using an open label, within-subjects protocol, 15 males and 5 females (mean age = 30.8 years) were administered three fixed, stepwise increasing sub-anaesthetic doses of intravenous (IV) ketamine solution [(i) 8 mg/h IV infusion plus 30 mg bolus, (ii) 12 mg/h IV infusion and (iii) 20 mg/h infusion]. Whole blood ketamine and norketamine concentrations were determined at each treatment step and at 2 h post-infusion. Driving performance was assessed at baseline, at each treatment step and at 2 h post-treatment using a validated computerised driving simulator. Standard Deviation of Lateral Position (SDLP) and Steering Variability (SV) were assessed. Linear Fixed Effect Modelling indicated a main effect for time (dose) for SDLP (F[4,72] = 33.22, p |
| Databáze: | OpenAIRE |
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