Effect of prostacyclin on the circulatory histamine during cardiopulmonary bypass
| Autor: | J. Beckett, J. J. Brannan, I. Fessatidis, K. M. Taylor, W. K. Man |
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| Rok vydání: | 1986 |
| Předmět: |
Male
Immunology Prostacyclin Toxicology Histamine Release Extracorporeal law.invention chemistry.chemical_compound Dogs law Cardiopulmonary bypass medicine Animals Pharmacology (medical) Pharmacology Cardiopulmonary Bypass Chemistry Heparin Epoprostenol Anesthesia Circulatory system Premedication Female Perfusion Histamine medicine.drug |
| Zdroj: | Agents and actions. 18(1-2) |
| ISSN: | 0065-4299 |
| Popis: | Changes in plasma histamien levels were studied in sixteen dogs under cardiopulmonary bypass (CPB) or bypass with the addition of prostacyclin (PGI2) infusion. In both groups, plasma histamine rose immediately after anaesthetic induction (median above pre-induction: 0.4 ng/ml) and following heparin infusion (median above pre-induction: 0.7 ng/ml). During CPB, plasma histamine levels were elevated throughout the 90 minute period of perfusion (median above pre-induction: 0.5–1.2 ng/ml). PGI2 infusion reduced the elevation in plasma histamine levels (median above pre-induction: 0–0.7 ng/ml). These data support the hypothesis that histamine release occurs during CPB. Platelet aggregation in the extracorporeal circuit may be contributory since prostacyclin premedication reduces histamine release. |
| Databáze: | OpenAIRE |
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