Neuroprotection by T-cells depends on their subtype and activation state
| Autor: | Robert Nitsch, Erik Kwidzinski, Barbara Steiner, Susanne A. Wolf, Ingo Bechmann, Jasmin Fisher |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Cell Survival
Ovalbumin T cell Immunology Central nervous system Stimulation Neuroprotection Epitopes Mice chemistry.chemical_compound Th2 Cells medicine Animals Immunology and Allergy Neurons Mice Inbred BALB C biology Contact Inhibition Brain Myelin Basic Protein Chemotaxis Th1 Cells Cell biology Myelin basic protein Chemotaxis Leukocyte medicine.anatomical_structure Animals Newborn Neurology chemistry Brain Injuries Nerve Degeneration Ionomycin biology.protein Cytokines Tetradecanoylphorbol Acetate Neurology (clinical) |
| Zdroj: | Journal of Neuroimmunology. 133:72-80 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/s0165-5728(02)00367-3 |
| Popis: | This study analyzes how the antigen specificity, the subtype, and the activation state of T cells modulate their recently discovered neuroprotective potential. We assessed the prevention from neuronal damage in organotypic entorhinal-hippocampal slice cultures after co-culture with Th1 and Th2 cells either specific for myelin basic protein (MBP) or ovalbumin (OVA). We found that MBP-specific Th2 cells were the most effective in preventing central nervous system (CNS) tissue from secondary injury. This neuroprotective T cell effect appears to be mediated by soluble factors. After stimulation with phorbol myristate acetate and ionomycin, all T cells were most effective in preventing neuronal death. Our data show that the T cell subtype and activation state are important features in determining the neuroprotective potential of these cells. |
| Databáze: | OpenAIRE |
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