Female gender and exogenous progesterone exposition as risk factors for spheno-orbital meningiomas
| Autor: | Caroline Le Guerinel, Marc Polivka, Dorian Chauvet, P. Roblot, Caroline Apra, Abdu Alkhayri |
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| Přispěvatelé: | Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, Fondation Ophtalmologique Adolphe de Rotschild, CHU Henri Mondor, Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Gestionnaire, HAL Sorbonne Université 5, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Nomegestrol acetate Cancer Research sphenoorbital meningioma Physiology cyproterone acetate osteomeningioma chemistry.chemical_compound 0302 clinical medicine Risk Factors Meningeal Neoplasms Orbital Diseases Progesterone Aged 80 and over Cyproterone acetate Middle Aged Prognosis progestin 3. Good health Menopause Neurology Oncology 030220 oncology & carcinogenesis Hormonal therapy Female [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Meningioma Chlormadinone medicine.drug Adult medicine.drug_class Skull Neoplasms 03 medical and health sciences Sex Factors Sphenoid Bone medicine Humans [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Etonogestrel Aged Retrospective Studies business.industry medicine.disease skull base meningioma Discontinuation nomegestrol acetate chemistry Neurology (clinical) Progestins business Progestin 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Journal of Neuro-Oncology Journal of Neuro-Oncology, Springer Verlag, 2020, 149 (1), pp.95-101. ⟨10.1007/s11060-020-03576-8⟩ Journal of Neuro-Oncology, 2020, 149 (1), pp.95-101. ⟨10.1007/s11060-020-03576-8⟩ |
| ISSN: | 0167-594X 1573-7373 |
| DOI: | 10.1007/s11060-020-03576-8⟩ |
| Popis: | International audience; ObjectiveThe great heterogeneity of meningiomas is challenging and we need to distinguish relevant subgroups. Spheno-orbital osteomeningiomas (SOOM) constitute a clinically specific entity, with slow-growing benign osteo-meningiomatous tumors, which recur after surgery in one fourth of cases. Neurosurgical daily practice, supported by the literature, shows that the vast majority of patients with SOOM are women, and we explored whether their epidemiological and hormonal profiles suggest a progesterone influence.MethodsWe retrospectively documented all radiologically and histologically confirmed cases of SOOM operated in 2005–2019 in our institution. We completed the clinical and hormone history by systematic telephone interviews.ResultsIn the literature, SOOM occur significantly more often in women than other meningiomas (749/847, 86.4% versus 73.8%, p = 0.002). Among 175 cases, we included 124 patients, 93.5% were women, younger than men (51 ± 5 versus 63 ± 8, p = 0.02). Women’ meningiomas showed more progesterone receptors (96.4% versus 50%, p |
| Databáze: | OpenAIRE |
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