Extended Gene Map Reveals Tripartite Motif, C-Type Lectin, and Ig Superfamily Type Genes within a Subregion of the Chicken MHC-B Affecting Infectious Disease
| Autor: | Sayoko Shimizu, Marcia M. Miller, Kazuyoshi Hosomichi, W. Elwood Briles, Kazuyo Yanagiya, Ronald M. Goto, Takashi Shiina, Hidetoshi Inoko |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Amino Acid Motifs
Molecular Sequence Data Immunology Genes MHC Class I Immunoglobulins chemical and pharmacologic phenomena Major histocompatibility complex Evolution Molecular MHC class I Genetic variation Marek Disease Animals Humans Immunology and Allergy Gene silencing Lectins C-Type Allele Gene Genetics biology Gene map Haplotype Chromosome Mapping Genetic Variation Immunity Innate Haplotypes Multigene Family biology.protein Chickens |
| Zdroj: | The Journal of Immunology. 178:7162-7172 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | MHC haplotypes have a remarkable influence on whether tumors form following infection of chickens with oncogenic Marek’s disease herpesvirus. Although resistance to tumor formation has been mapped to a subregion of the chicken MHC-B region, the gene or genes responsible have not been identified. A full gene map of the subregion has been lacking. We have expanded the MHC-B region gene map beyond the 92-kb core previously reported for another haplotype revealing the presence of 46 genes within 242 kb in the Red Jungle Fowl haplotype. Even though MHC-B is structured differently, many of the newly revealed genes are related to loci typical of the MHC in other species. Other MHC-B loci are homologs of genes found within MHC paralogous regions (regions thought to be derived from ancient duplications of a primordial immune defense complex where genes have undergone differential silencing over evolutionary time) on other chromosomes. Still others are similar to genes that define the NK complex in mammals. Many of the newly mapped genes display allelic variability and fall within the MHC-B subregion previously shown to affect the formation of Marek’s disease tumors and hence are candidates for genes conferring resistance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|