Increased serum renalase in hemodialysis patients: is it related to left ventricular hypertrophy?

Autor:	M. Deniz Ayli, Tolga Yildirim, Ozlem Yayar, Ebru Gok Oguz, Basol Canbakan, Güner Karaveli Gürsoy, Cengiz Bulut, Baris Eser, Tolga Çimen, Ekrem Yeter
Rok vydání:	2016
Předmět:	Adult Male medicine.medical_specialty Turkey Anemia medicine.medical_treatment Heart Ventricles 030232 urology & nephrology 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Left ventricular hypertrophy End stage renal disease 03 medical and health sciences 0302 clinical medicine Renal Dialysis Risk Factors Internal medicine Diabetes mellitus Medicine Humans Monoamine Oxidase Dialysis Renalase Aged biology business.industry C-reactive protein General Medicine Middle Aged medicine.disease Echocardiography Doppler Color C-Reactive Protein Cross-Sectional Studies Nephrology Case-Control Studies Creatinine biology.protein Cardiology Kidney Failure Chronic Regression Analysis Female Hypertrophy Left Ventricular Hemodialysis business
Zdroj:	Renal failure. 38(8)
ISSN:	1525-6049
Popis:	Left ventricular hypertrophy (LVH) is one of the most common cardiac abnormalities in patients with end stage renal disease (ESRD). Hypertension, diabetes, increased body mass index, gender, age, anemia, and hyperparathyroidism have been described as risk factors for LVH in patients on dialysis. However, there may be other risk factors which have not been described yet. Recent studies show that renalase is associated with cardiovascular events. The aim of this study was to reveal the relation between renalase, LVH in patients under hemodialysis (HD) treatment.The study included 50 HD patients and 35 healthy controls. Serum renalase levels and left ventricle mass index (LVMI) were measured in all participants and the relation between these variables was examined.LVMI was positively correlated with dialysis vintage and C-reactive protein (CRP) (r = 0.387, p = 0.005 and r = 0.597, p 0.001, respectively) and was negatively correlated with residual diuresis and hemoglobin levels (r = -0.324, p = 0.022 and r = -0.499, p 0.001, respectively). There was no significant association of renalase with LVMI in the HD patients (r = 0.263, p = 0.065). Serum renalase levels were significantly higher in HD patients (212 ± 127 ng/mL) compared to controls (116 ± 67 ng/mL) (p 0.001). Renalase was positively correlated with serum creatinine and dialysis vintage (r = 0.677, p 0.001 and r = 0.625, p 0.001, respectively).In our study, LVMI was correlated with dialysis vintage, residual diuresis, CRP, and hemoglobin. LVMI tends to correlate with renalase and this correlation may be significant in studies with more patient numbers. The main parameters affecting renalase levels are dialysis vintage and serum creatinine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1769a3a91f4dafbdb5deccd78b40da2 https://pubmed.ncbi.nlm.nih.gov/27416751 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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