Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10
| Autor: | A. Geurts van Kessel, E van Drunen, C. H. van Dalen, R. Verheijen, H. J. H. Kuijpers, D. Schonk, F. C. S. Ramaekers |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.drug_class
Somatic cell Immunoblotting Gene Expression Hybrid Cells Monoclonal antibody Antigen Proliferating Cell Nuclear Antigen Gene expression Genetics medicine Animals Humans Genetics (clinical) biology Chromosomes Human Pair 10 Antibodies Monoclonal Chromosome Mapping Nuclear Proteins Molecular biology Proliferating cell nuclear antigen Ki-67 Immunology biology.protein Somatic antigen Antibody |
| Zdroj: | Human Genetics. 83:297-299 |
| ISSN: | 1432-1203 0340-6717 |
| DOI: | 10.1007/bf00285178 |
| Popis: | The antigen recognized by the monoclonal antibody Ki-67 is a proliferation-related nucleolus-associated constituent used as a marker for cycling cells in tumor diagnosis. Antibody Ki-67 reacts with human proliferating cells, but not with hamster and mouse cells. Expression of the Ki-67 antigen was studied in a panel of human-rodent somatic cell hybrids. The results indicate that a gene involved in the expression of the antigen is located on chromosome 10. |
| Databáze: | OpenAIRE |
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