Plakinidine D, a New Pyrroloacridine Alkaloid from Two Ascidians of the Genus Didemnum
| Autor: | Akbar Tahir, Jamaluddin Jompa, Faulkner Dj, Venables Da, Hopmann C, Ireland Cm, Cameron J. Smith, Christine E. Salomon |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry Pharmaceutical Science Antineoplastic Agents Biology Analytical Chemistry Alkaloids Genus Spectroscopy Fourier Transform Infrared Drug Discovery Botany Tumor Cells Cultured Animals Humans Urochordata Plakinidine D Didemnum Pharmacology Alkaloid Organic Chemistry biology.organism_classification Complementary and alternative medicine Molecular Medicine Spectrophotometry Ultraviolet Drug Screening Assays Antitumor Didemnum sp |
| Zdroj: | Journal of Natural Products. 60:1048-1050 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | A previously undescribed red Didemnum sp. collected in Indonesia contained a novel pyrroloacridine, plakinidine D (4), along with the known compounds 3,5-diiodo-4-methoxyphenethylamine (5) and ascididemin (6), both of which had previously been isolated from ascidians of the genus Didemnum. Plakinidine D (4) and 3,5-diiodo-4-methoxyphenethylamine (5) were also isolated from Didemnum rubeum from the Republic of Palau. Interestingly, a collection of D. rubeum from Indonesia did not contain plakinidine D (4), but instead contained 3,5-diiodo-4-methoxyphenethylamine (5) and ascididemin (6). The structure of plakinidine D (4) was elucidated by analysis of its spectral data. Plakinidine D (4) is closely related to plakinidines A-C (1-3), previously isolated from the sponge Plakortis sp. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|