Effects of sodium β-sitosteryl sulfate on the phase behavior of dipalmitoylphosphatidylcholine

Autor: Ananda Kafle, Avinash Bhadani, Takeshi Misono, Hideki Sakai, Teruhisa Kaneko, Chihiro Kaise, Kenichi Sakai
Rok vydání: 2018
Předmět:
0301 basic medicine
1
2-Dipalmitoylphosphatidylcholine
Membrane Fluidity
Sodium
Lipid Bilayers
chemistry.chemical_element
02 engineering and technology
Phase Transition
03 medical and health sciences
chemistry.chemical_compound
Colloid and Surface Chemistry
Microscopy
Electron
Transmission
X-Ray Diffraction
Phase (matter)
Phosphatidylcholine
Scattering
Small Angle
Freeze Fracturing
Transition Temperature
Physical and Theoretical Chemistry
Sulfate
chemistry.chemical_classification
Chromatography
030102 biochemistry & molecular biology
Chemistry
Small-angle X-ray scattering
Surfaces and Interfaces
General Medicine
021001 nanoscience & nanotechnology
Sitosterols
Cholesterol
Membrane
Hydrocarbon
Dipalmitoylphosphatidylcholine
lipids (amino acids
peptides
and proteins)
0210 nano-technology
Biotechnology
Nuclear chemistry
Zdroj: Colloids and Surfaces B: Biointerfaces. 161:59-66
ISSN: 0927-7765
DOI: 10.1016/j.colsurfb.2017.10.014
Popis: We have studied the phase behavior of dipalmitoylphosphatidylcholine (DPPC) containing sodium β-sitosteryl sulfate (PSO4). PSO4 was found to lower the phase transition temperature of DPPC to a higher degree than cholesterol or β-sitosterol. It also gave rise to the formation of a modulated (ripple) phase (Pβ) at low to moderate concentrations. At concentrations greater than 25 mol%, it completely changed the membrane into a fluid phase. This shows that PSO4 is capable of disordering the hydrocarbon chains of PC efficiently. The characteristics of PSO4 for fluidizing the membrane can be useful for the pharmaceutical and cosmetics industries.
Databáze: OpenAIRE
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