PUVA Induced Bullous Pemphigoid in a Patient with Mycosis Fungoides
| Autor: | Ayşe Akman-Karakaş, Soner Uzun, Saliha Koç, Ertan Yilmaz, Birgül Özkesici, Ibrahim Bassorgun |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.medical_treatment Case Report Physical examination Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine lcsh:Dermatology medicine skin and connective tissue diseases Direct fluorescent antibody Basement membrane Mycosis fungoides integumentary system medicine.diagnostic_test business.industry Autoantibody Blisters lcsh:RL1-803 medicine.disease eye diseases medicine.anatomical_structure 030220 oncology & carcinogenesis PUVA therapy Bullous pemphigoid medicine.symptom business |
| Zdroj: | Case Reports in Dermatological Medicine, Vol 2017 (2017) Case Reports in Dermatological Medicine |
| ISSN: | 2090-6471 2090-6463 |
| DOI: | 10.1155/2017/6134752 |
| Popis: | Background. Bullous pemphigoid is an autoimmune subepidermal blistering skin disease in which autoantibodies are directed against components of the basement membrane. The disease primarily affects the elderly people and in most of the patients inducing factors cannot be identified. Herein, we report a case of BP that occurred in a patient who was receiving PUVA therapy for the treatment of mycosis fungoides. Main Observation. A 26-year-old woman with mycosis fungoides developed blisters while receiving PUVA therapy. On physical examination tense bullae on the normal skin, remnants of blisters, and erosions were observed on her breasts, the chest wall, and the upper abdomen. Histopathological investigations revealed subepidermal blisters with eosinophilic infiltration and in direct immunofluorescence examination linear deposition of IgG along the basement membrane zone was observed. The diagnosis of bullous pemphigoid was also confirmed by ELISA and BIOCHIP mosaic-based indirect immunofluorescence test. Conclusions. PUVA therapy is an extremely rare physical factor capable of inducing bullous pemphigoid. So the development of blistering lesions during PUVA therapy may be suggestive sign of a bullous disease such as bullous pemphigoid and it should be excluded with proper clinical and laboratory approaches immediately after withdrawal of PUVA therapy. |
| Databáze: | OpenAIRE |
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