Higher prevalence of autoantibodies to insulin and GAD65 in Swedish compared to Lithuanian children with type 1 diabetes
| Autor: | Vaiva Sadauskaitė – Kuehne, Žilvinas Padaiga, Johnny Ludvigsson, Outi Vaarala, Hanna Holmberg, Jorma Ilonen |
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| Rok vydání: | 2006 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Adolescent Insulin Antibodies Endocrinology Diabetes and Metabolism medicine.medical_treatment Glutamate decarboxylase Autoimmunity Human leukocyte antigen HLA-DR3 Antigen Endocrinology HLA-DQ Antigens Insulin-Secreting Cells Internal medicine Diabetes mellitus HLA-DR4 Antigen Internal Medicine medicine Humans Insulin Genetic Predisposition to Disease Child Autoantibodies Glycated Hemoglobin Sweden Type 1 diabetes Polymorphism Genetic Glutamate Decarboxylase business.industry Haplotype Autoantibody Case-control study Infant Lithuania General Medicine medicine.disease Isoenzymes Cross-Sectional Studies Diabetes Mellitus Type 1 Haplotypes Case-Control Studies Child Preschool Female business |
| Zdroj: | Diabetes Research and Clinical Practice. 72:308-314 |
| ISSN: | 0168-8227 |
| Popis: | We compared the prevalence of beta-cell autoantibodies and genetic risk factors in Sweden and Lithuania. Ninety-six patients from Sweden and 96 from Lithuania matched for age and gender (1-15 years old, median age 9.0 years) were included. We analyzed autoantibodies to insulin (IAA), glutamic acid decarboxylase (GADA) and the protein tyrosine phosphatase like IA-2 (IA-2A) as well as risk-associated polymorphisms of HLA, insulin and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) genes. The frequency of patients positive for IAA and GADA was higher in Sweden than in Lithuania (p = 0.043 and 0.032). The differences remained even when the patients were matched for HLA, insulin and CTLA-4 risk genotypes. Patients with low levels of IAA had higher levels of HbA1c and ketones at diagnosis. The frequency of the risk haplotype DR4-DQ8 was higher in Swedish than in Lithuanian patients (p = 0.004), as well as the high-risk combination of DR4-DQ8 and DR3-DQ2 haplotypes (p = 0.009). Our results suggest that autoimmune process against insulin and GAD(65) is more common at diagnosis in children in areas with high incidence of type 1 diabetes (T1D), independent of genetic risk markers. Furthermore, the disease in patients with insulin autoantibodies seems to be clinically milder. |
| Databáze: | OpenAIRE |
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