Patterns of drug prescriptions in an orthogeriatric ward as compared to orthopaedic ward: results from the Trondheim Hip Fracture Trial-a randomised clinical trial
| Autor: | Ingvild Saltvedt, Marianne Heltne, Stian Lydersen, Anders Prestmo, Olav Sletvold, Olav Spigset |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Hospital Departments Fear of falling Drug Prescriptions Hip fracture 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Quality of life Rating scale Medicine Humans Pharmacology (medical) 030212 general & internal medicine Medical prescription Aged Pharmacology Polypharmacy Aged 80 and over business.industry Hip Fractures General Medicine medicine.disease Clinical Trial Frail elderly Drug Utilization Geriatric assessment Clinical trial Hospitalization Orthopedics Geriatrics Physical therapy Quality of Life Comprehensive geriatric care Female medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Clinical Pharmacology |
| ISSN: | 1432-1041 |
| Popis: | Purpose In the Trondheim Hip Fracture Trial, 397 home-dwelling patients with hip fractures were randomised to comprehensive geriatric care (CGC) in a geriatric ward or traditional orthopaedic care (OC). Patients in the CGC group had significantly better mobility and function 4 months after discharge. This study explores group differences in drug prescribing and possible associations with the outcomes in the main study. Methods Drugs prescribed at admission and discharge were registered from hospital records. Mobility, function, fear of falling and quality of life were assessed using specific rating scales. Linear regression was used to analyse association between drug changes and outcomes at 4 months. Results The mean age was 83 years, and 74% were females. The mean number (± SD) of drugs in the CGC and OC groups was 3.8 (2.8) and 3.9 (2.8) at inclusion and 7.1 (2.8) and 6.2 (3.0) at discharge, respectively (p = 0.003). The total number of withdrawals was 209 and 82 in the CGC and OC groups, respectively (p < 0.0001), and the number of starts was 844 and 526, respectively (p < 0.0001). A significant negative association was found between the number of drug changes during the hospital stay and mobility and function 4 months later in both groups. However, this association disappeared when adjusting for baseline function and comorbidities. Conclusion These secondary analyses suggest that there are significant differences in the pharmacological treatment between geriatric and orthopaedic wards, but these differences could not explain the beneficial effect of CGC in the Trondheim Hip Fracture Trial. © The Author(s) 2017. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink