The association between smoking and the development of psoriatic arthritis among psoriasis patients
| Autor: | Richard J. Cook, Arane Thavaneswaran, Lihi Eder, Vinod Chandran, Dafna D. Gladman, Cheryl F. Rosen, Sutha Shanmugarajah |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcohol Drinking Immunology Arthritis Subgroup analysis HLA-C Antigens urologic and male genital diseases Logistic regression General Biochemistry Genetics and Molecular Biology Psoriatic arthritis Age Distribution Rheumatology Internal medicine Psoriasis Epidemiology medicine Humans Immunology and Allergy Ontario business.industry Histocompatibility Testing Arthritis Psoriatic Smoking Confounding Case-control study Middle Aged medicine.disease Case-Control Studies Physical therapy Female business |
| Zdroj: | Annals of the Rheumatic Diseases. 71:219-224 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/ard.2010.147793 |
| Popis: | Aim To investigate the association between smoking and psoriatic arthritis (PsA) among patients with psoriasis and its interaction with the HLA-C*06 allele. Methods In this exploratory case–control study, smoking status was determined at the time of the diagnosis of arthritis for PsA patients and at their first study visit for psoriasis patients, when they were confirmed not to have PsA. The proportions of patients exposed to smoking were compared in patients with PsA to those with psoriasis alone. A logistic regression model was constructed to test the independent association of smoking and PsA after adjusting for potential confounders. The statistical interaction between HLA-C*06 and smoking was tested through a regression model. Results The proportions of current and past smokers were higher in the psoriasis group compared with the PsA group (30.2% vs 23.4% and 26.7% vs 22.3%, p=0.001, respectively). On multivariate analysis being a current smoker versus a lifetime non-smoker remained inversely associated with PsA (OR 0.57, p=0.002), while past smoker versus lifetime non-smoker status was no longer significant. In a subgroup analysis, smoking remained inversely associated with PsA only among patients who were HLA-C*06 negative. Regression analysis revealed that the interaction between smoking status (ever smoked vs lifetime non-smoker) and HLA-C*06 was statistically significant (p=0.01). Conclusion Smoking may be inversely associated with PsA among psoriasis patients. This association is not present among HLA-C*06-positive individuals. |
| Databáze: | OpenAIRE |
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