The effect of tamoxifen on cervical squamous maturation in Papanicolaou stained cervical smears of post-menopausal women
| Autor: | T. P. Eells, C. Grzywacz, R. W. MacMILLAN, J. E. Olson, H. D. Alpern |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Oncology
medicine.medical_specialty Histology Papanicolaou stain Breast Neoplasms Cervix Uteri Adenocarcinoma Epithelium Pathology and Forensic Medicine Internal medicine medicine Carcinoma Humans False Positive Reactions skin and connective tissue diseases Cervix Aged Vaginal Smears Gynecology business.industry Cancer Cell Differentiation Epithelial Cells Retrospective cohort study General Medicine Papanicolaou Test Middle Aged medicine.disease Stimulation Chemical Menopause Tamoxifen medicine.anatomical_structure Uterine Neoplasms Female business medicine.drug |
| Zdroj: | Cytopathology. 1:263-268 |
| ISSN: | 1365-2303 0956-5507 |
| Popis: | Using cervical smears obtained as part of routine gynaecological examinations, a retrospective study of the effects of the drug tamoxifen on squamous epithelial maturation of the cervix of post-menopausal women being treated for advanced breast cancer was made. The degree of squamous epithelial maturation was quantitated by using the Maturation Index and the Maturation Value. Although tamoxifen is a synthetic, non-steroidal compound classified as anti-oestrogenic, the findings indicate that this drug commonly produces a level of squamous maturation indicative of oestrogenic stimulation in Papanicolaou stained cervical smears from post-menopausal patients receiving this drug. Knowledge of the oestrogenic effect of tamoxifen in the cervix can obviate clinical concern about endometrial carcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text