Induction of transplantation tolerance in adult rats by vascularized spleen transplantation
| Autor: | Megumu Miyamoto, Yuuichi Hattori, Hidetoshi Suzuki, Tuguo Sano, Xing-Hua Li, Akira Yamashita |
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| Rok vydání: | 1997 |
| Předmět: |
Graft Rejection
Male Pathology medicine.medical_specialty medicine.medical_treatment Spleen Major histocompatibility complex Tacrolimus Immune tolerance Transplantation Immunology Rats Inbred BN Minor histocompatibility antigen Immune Tolerance Medicine Animals Transplantation Chemotherapy biology business.industry Spleen transplantation Graft Survival Skin Transplantation Rats Rats Inbred ACI surgical procedures operative medicine.anatomical_structure Rats Inbred Lew Immunology biology.protein Female business |
| Zdroj: | Transplantation. 64(4) |
| ISSN: | 0041-1337 |
| Popis: | It was demonstrated by Bitter-Seurmann et al. that tolerance to subsequent skin allografts can be brought about, in some rat strain combinations, by heterotopic spleen allografts. We report here that in adult rats, tolerance can be also induced by vascularized spleen allografts using various strain combinations. DA (RT1av1) rats always accepted major histocompatible complex (MHC)-compatible but minor histocompatibility antigen (miH)-incompatible ACI (RT1av1) spleen grafts spontaneously, and further that those DA rats bearing ACI spleen grafts accepted subsequent ACI skin grafts indefinitely. In contrast, Fischer 344 (RT1lvl) rats always accepted not only the "weak" MHC-incompatible Lewis (RT1l) spleen grafts but also subsequent Lewis skin grafts indefinitely, when recipients were administered a short course of FK506 only at the time of primary spleen transplantation. Furthermore, in a number of MHC- and miH-incompatible strain combinations, recipients always accepted primary spleen grafts indefinitely when given a short course of FK506, but those recipients bearing donor spleens revealed split tolerance, that is, rejected subsequent donor-specific skin grafts but accepted heart grafts indefinitely. We conclude that the spleen seems to be a possible organ to induce transplantation tolerance, and that even if the MHC and miH are mismatched, unresponsiveness to at least heart grafts can be achieved by the administration of additional FK506 at the time of spleen transplantation. |
| Databáze: | OpenAIRE |
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