Genetic diversity of simian immunodeficiency viruses from west African green monkeys : evidence of multiple genotypes within populations from the same geographical locale
| Autor: | C. Brengues, G Galat, Gérard Cuny, Frederic Bibollet-Ruche, J.P. Durand, Nicole Vidal, Xavier Pourrut, F. Veas, A. Galat-Luong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Genotype
viruses Immunology Population Molecular Sequence Data Retroviridae Proteins Oncogenic SIV.SIMIAN IMMUNODEFICIENCY VIRUS VIROSE Biology Simian medicine.disease_cause Microbiology Cercopithecus aethiops Polymerase Chain Reaction SINGE Evolution Molecular GENETIQUE DE POPULATION Virology Genetic variation Chlorocebus aethiops medicine Animals Humans PHYLOGENIE Amino Acid Sequence education Phylogeny Genetics education.field_of_study Genetic diversity Phylogenetic tree Base Sequence Sequence Homology Amino Acid Gene Products env Genetic Variation Simian immunodeficiency virus biology.organism_classification HOTE VERTEBRE GENOTYPE Genes rev Genes tat Insect Science DNA Viral POLYMORPHISME GENETIQUE Simian Immunodeficiency Virus African Green Monkey Viral Fusion Proteins AGENT PATHOGENE Research Article |
| Popis: | High simian immunodeficiency virus (SIV) seroprevalence rates have been reported in the different African green monkey (AGM) subspecies. Genetic diversity of these viruses far exceeds the diversity observed in the other lentivirus-infected human and nonhuman primates and is thought to reflect ancient introduction of SIV in the AGM population. We investigate here genetic diversity of SIVagm in wild-living AGM populations from the same geographical locale (i.e., sympatric population) in Senegal. For 11 new strains, we PCR amplified and sequenced two regions of the genome spanning the first tat exon and part of the transmembrane glycoprotein. Phylogenetic analysis of these sequences shows that viruses found in sympatric populations cluster into distinct lineages, with at least two distinct genotypes in each troop. These data strongly suggest an ancient introduction of these divergent viruses in the AGM population. |
| Databáze: | OpenAIRE |
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