MELD-based graft allocation system fails to improve liver transplantation efficacy in a single-center intent-to-treat analysis

Autor: Karim Boudjema, Bernard Meunier, Christophe Camus, Vianney Bouygues, M. Lakehal, Philippe Compagnon, Edouard Bardou-Jacquet, Marianne Latournerie
Přispěvatelé: Le Corre, Morgane, Service de Chirurgie Hépatobiliaire et Digestive [Rennes] = Hepatobiliary and Digestive Surgery [Rennes], CHU Pontchaillou [Rennes], Service des maladies du foie [CHU Rennes], Centre Hospitalier Universitaire [Rennes], Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], Service des maladies du foie, Centre Hospitalier Universitaire [Rennes]-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
medicine.medical_specialty
MESH: Liver Transplantation
medicine.medical_treatment
030230 surgery
Liver transplantation
Single Center
MESH: Intention to Treat Analysis
03 medical and health sciences
0302 clinical medicine
medicine
Humans
MESH: Patient Selection
10. No inequality
MESH: Models
Theoretical
Survival rate
Retrospective Studies
Intention-to-treat analysis
MESH: Humans
MESH: Middle Aged
Hepatology
business.industry
Incidence (epidemiology)
Patient Selection
Disease progression
Gastroenterology
Retrospective cohort study
MESH: Retrospective Studies
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Middle Aged
Models
Theoretical
[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
MESH: Male
3. Good health
Surgery
Intention to Treat Analysis
Liver Transplantation
Transplantation
body regions
030211 gastroenterology & hepatology
Female
business
MESH: Female
Zdroj: Clinics and Research in Hepatology and Gastroenterology
Clinics and Research in Hepatology and Gastroenterology, Elsevier, 2012, 36 (5), pp.464-72. ⟨10.1016/j.clinre.2012.07.009⟩
ISSN: 2210-7401
2210-741X
DOI: 10.1016/j.clinre.2012.07.009⟩
Popis: International audience; BACKGROUND: Since March 2007, priority access to liver transplantation in France has been given to patients with the highest MELD scores. OBJECTIVE: To undertake an intent-to-treat comparison of center-based vs. MELD-based liver graft allocation. METHODS: Retrospective cohort analysis (patients listed 6th March 2007 to 5th March 2009; MELD period) with a matched historical cohort (patients listed 6th March 2005 to 5th March 2007; pre-MELD period) in a single high-volume center. Analysis was on an intent-to-treat basis, i.e. starting on the day of wait listing. RESULTS: Compared to pre-MELD, fewer patients with a MELD score less or equal to 14 (P=0.002), and more patients with a MELD greater or equal to 24 (P
Databáze: OpenAIRE
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