Association between Allosensitization and Waiting List Outcomes among Adult Lung Transplant Candidates in the United States
| Autor: | K.B. Bain, Roger D. Yusen, Ramsey R. Hachem, K.A. Fester, Varun Puri, Patrick R. Aguilar, Thalachallour Mohanakumar, Hrishikesh S. Kulkarni, L.K. Tague, Chad A. Witt, Derek E. Byers, Elbert P. Trulock, Daniel Kreisel |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Tissue and Organ Procurement Waiting Lists Allosensitization medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine HLA Antigens Isoantibodies medicine Humans Lung transplantation 030212 general & internal medicine Intensive care medicine Retrospective Studies Original Research Lung business.industry Patient Selection Middle Aged respiratory system United States respiratory tract diseases surgical procedures operative medicine.anatomical_structure 030228 respiratory system Waiting list Multivariate Analysis Female business Lung Transplantation |
| Zdroj: | Ann Am Thorac Soc |
| ISSN: | 2325-6621 2329-6933 |
| Popis: | Rationale: Allosensitization may be a barrier to lung transplant. Currently, consideration is not given to allosensitization when assigning priority on the lung transplant waiting list. Objectives: We aimed to examine the association between allosensitization and waiting list outcomes. Methods: We conducted a retrospective single-center cohort study of adults listed for lung transplant at our center between January 1, 2006, and December 31, 2016. We screened candidates for human leukocyte antigen antibodies before listing and examined the association between allosensitization and waiting list outcomes, including likelihood of transplant and death on the waiting list, using a competing risk model. Calculated panel-reactive antibody (CPRA) was used as a continuous measure of allosensitization. Results: Among 746 candidates who were listed for lung transplant during the study period, 263 (35%) were allosensitized, and 483 (65%) were not. In unadjusted analysis, allosensitized candidates had a decreased likelihood of transplant compared with nonallosensitized candidates (subhazard ratio [sHR], 0.71; 95% confidence interval [CI], 0.60–0.83; P |
| Databáze: | OpenAIRE |
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