Impact of short stature on quality of life: A systematic literature review
| Autor: | Charlotte Cookson, Marco Cappa, Caroline Sert, Mehul T. Dattani, Philippe Backeljauw, Lisa Law, Wieland Kiess, John D Whalen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Parents 0301 basic medicine Pediatrics medicine.medical_specialty Endocrinology Diabetes and Metabolism Caregiver Burden 030209 endocrinology & metabolism Short stature Achondroplasia Growth hormone deficiency 03 medical and health sciences 0302 clinical medicine Endocrinology Cost of Illness Quality of life medicine Humans Renal Insufficiency Chronic Child Growth Disorders Human Growth Hormone business.industry beta-Thalassemia Caregiver burden medicine.disease Body Height Idiopathic short stature 030104 developmental biology Systematic review Infant Small for Gestational Age Quality of Life Small for gestational age medicine.symptom business |
| Zdroj: | Growth Hormone & IGF Research. :101392 |
| ISSN: | 1096-6374 |
| Popis: | Objective We sought to obtain a better understanding of the burden of short stature using a systematic literature review. Methods Studies of the burden of short stature, of any cause in adults and children, were searched using Embase, MEDLINE and Cochrane databases in April 2020, capturing publications from 2008 onwards. Case series and populations with adult-onset growth hormone deficiency (GHD) were excluded. Results Of 1684 publications identified, 41 studies (33 in children, 8 in adults) were included. All studies assessed human burden. Most study populations in children included short stature due to GHD, idiopathic short stature (ISS) and short stature after being born small for gestational age (SGA). In these populations, four studies showed that quality of life (QoL) in children with short stature was significantly worse than in children with normal stature. A significant association between QoL and short stature was observed in children with chronic kidney disease (CKD) (3 studies), achondroplasia (1 study) and transfusion-dependent β-thalassaemia (1 study), and in samples with mixed causes of short stature (3 studies). Three studies (one in GHD/ISS/SGA and two in CKD) found no significant association between short stature and QoL, and several studies did not report statistical significance. Approximately half of adult studies showed that QoL was reduced with short stature, and the other half showed no association. Two studies, one in adults with Prader–Willi syndrome and one in children with GHD, suggested a potential association between short stature and poorer cognitive outcomes. Three studies demonstrated an increased caregiver burden in parents of children with short stature. Conclusions Evidence suggests that, compared with those with normal stature, children and adults with short stature of any cause may experience poorer QoL. Further research could extend our understanding of the human burden in this field. |
| Databáze: | OpenAIRE |
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