The Native Fruit Geoffroea decorticans from Arid Northern Chile: Phenolic Composition, Antioxidant Activities and In Vitro Inhibition of Pro-Inflammatory and Metabolic Syndrome-Associated Enzymes
| Autor: | Guillermo Schmeda-Hirschmann, Cristina Theoduloz, Iris Catiana Zampini, Maria Del Pilar C. Soriano, María Inés Isla, Mario J. Simirgiotis, Maider Ugalde-Arbizu, María Rosa Alberto, Felipe Jiménez-Aspee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Antioxidant
Flavonols medicine.medical_treatment Lipoxygenase Anti-Inflammatory Agents Pharmaceutical Science antioxidant capacity HPLC-DAD-ESI-MS Antioxidants Catechin Analytical Chemistry purl.org/becyt/ford/1 [https] Geoffroea decorticans anti-inflammatory activity phenolic composition metabolic syndrome-associated enzymes Drug Discovery Food science Chile chemistry.chemical_classification Metabolic Syndrome biology GEOFFROEA DECORTICANS Fabaceae 04 agricultural and veterinary sciences 040401 food science Proanthocyanidin Chemistry (miscellaneous) Phospholipases METABOLIC SYNDROME-ASSOCIATED ENZYMES Molecular Medicine Alpha-amylase CIENCIAS NATURALES Y EXACTAS Cell Survival Otras Ciencias Biológicas Article ANTI-INFLAMMATORY ACTIVITY lcsh:QD241-441 Ciencias Biológicas ANTIOXIDANT CAPACITY 0404 agricultural biotechnology lcsh:Organic chemistry Phenols Botany medicine Biflavonoids Humans Proanthocyanidins Physical and Theoretical Chemistry purl.org/becyt/ford/1.6 [https] Plant Extracts Organic Chemistry Glycoside alpha-Glucosidases Fibroblasts biology.organism_classification PHENOLIC COMPOSITION chemistry Alpha-glucosidase Polyphenol Fruit biology.protein |
| Zdroj: | Molecules; Volume 22; Issue 9; Pages: 1565 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Molecules, Vol 22, Iss 9, p 1565 (2017) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules22091565 |
| Popis: | The native tree Geoffroea decorticans (cha ar) grows in the arid lands of northern Chile. It has been used as a food plant since prehistoric times. Phenolic-enriched extracts (PEEs) of Chilean cha ar fruits were assessed for their chemical composition, antioxidant properties and inhibition of pro-inflammatory and metabolic syndrome-associated enzymes. Phenolic profiles were determined by HPLC-DAD-MS/MS. The PEEs of G. decorticans showed a strong effect towards the enzymes COX-1/COX-2, with inhibition percentages ranging from inactive to 92.1% and inactive to 76.0% at 50 µg PEE/mL, respectively. The IC50 values of the PEEs towards lipoxygenase and phospholipase A2 inhibitory activity were between 43.6–96.8 and 98.9–156.0 µg PEE/mL, respectively. Samples inhibited α-glucosidase (IC50 0.8–7.3 µg PEE/mL) and lipase (9.9 to 100 µg PEE/mL). However, samples did not inhibit α-amylase. The HPLC-DAD-MS analysis of the PEEs allowed the tentative identification of 53 compounds, mainly flavonol glycosides and procyanidins. The procyanidin content of the Chilean G. decorticans pulp was positively correlated with the antioxidant activity and the inhibition of the enzyme α-glucosidase. These results indicate that the Chilean cha ar fruit contains bioactive polyphenols with functional properties. Fil: Jiménez Aspee, Felipe. Universidad de Talca; Chile Fil: Theoduloz, Cristina. Universidad de Talca; Chile Fil: Soriano, María del Pilar C.. Universidad de Talca; Chile Fil: Ugalde Arbizu, Maider. Universidad de Talca; Chile Fil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina Fil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina Fil: Simirgiotis, Mario J.. Universidad Austral de Chile; Chile Fil: Schmeda Hirschmann, Guillermo. Universidad de Talca; Chile |
| Databáze: | OpenAIRE |
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