Primary Sjögren Syndrome Complicated by Autoimmune Hemolytic Anemia and Pure Red Cell Aplasia
| Autor: | Sotiria Michalopoulou, Charalambos Gogos, Alexandra Lekkou, Christos Papakonstantinou, Maria Melachrinou, Nikolaos C. Giannakoulas, Stelios F Assimakopoulos |
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| Rok vydání: | 2007 |
| Předmět: |
Hemolytic anemia
Autoimmune disease Acquired Pure Red Cell Aplasia business.industry Anemia Pure red cell aplasia General Medicine Red-Cell Aplasia Pure medicine.disease Connective tissue disease Diagnosis Differential stomatognathic diseases Sjogren's Syndrome Bone Marrow hemic and lymphatic diseases Immunology medicine Humans Female Anemia Hemolytic Autoimmune Autoimmune hemolytic anemia Aplastic anemia business Aged |
| Zdroj: | The American Journal of the Medical Sciences. 334:493-496 |
| ISSN: | 0002-9629 |
| Popis: | Patients with primary Sjögren syndrome frequently present hematologic abnormalities, consisting mainly of immune cytopenias. Pure red cell aplasia is a very rare complication of primary Sjögren syndrome. This is the first report in the literature describing the development of pure red cell aplasia combined with autoimmune hemolytic anemia in a 74-year-old woman with primary Sjögren syndrome. In our patient, despite administration of diverse therapeutic schemes, such as corticosteroids, immunomodulating agents (intravenous immune globulin), immunosuppressive drugs (cyclophosphamide), and novel treatment options (monoclonal antibody directed against the CD20 antigen), no response was achieved. The present case suggests that the possibility of comorbid connective tissue disease should be a diagnostic consideration in patients with acquired pure red cell aplasia and autoimmune hemolytic anemia. Although most of the hematologic abnormalities that occur in primary Sjögren syndrome are not clinically significant, serious and difficult-to-treat hematologic complications may also occur. |
| Databáze: | OpenAIRE |
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