Antineoplastic Agents. 570. Isolation and Structure Elucidation of Bacillistatins 1 and 2 from a Marine Bacillus silvestris

Autor:	Jean-Charles Chapuis, Venugopal J. R. V. Mukku, Robin K. Pettit, Delbert L. Herald, John Hamblin, Fiona Hogan, John C. Knight, Michael J. Dodson, George R. Pettit
Rok vydání:	2009
Předmět:	Male Models Molecular Stereochemistry Molecular Conformation Pharmaceutical Science Bacillus Antineoplastic Agents Marine Biology Microbial Sensitivity Tests Crystallography X-Ray Article Analytical Chemistry Mice Depsipeptides Drug Resistance Multiple Bacterial Drug Discovery Animals Humans Nuclear Magnetic Resonance Biomolecular Antibacterial agent Pharmacology Depsipeptide chemistry.chemical_classification Bacillaceae Molecular Structure biology Organic Chemistry Stereoisomerism biology.organism_classification Bacillales Cyclic peptide Complementary and alternative medicine Biochemistry chemistry Molecular Medicine Female Drug Screening Assays Antitumor Two-dimensional nuclear magnetic resonance spectroscopy Bacteria
Zdroj:	Journal of Natural Products. 72:366-371
ISSN:	1520-6025 0163-3864
DOI:	10.1021/np800603u
Popis:	Two new cyclodepsipeptides designated bacillistatins 1 (1) and 2 (2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI(50)'s of 10(-4)-10(-5) microg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1647ff874d4befd202d9051fdbd57e5 https://doi.org/10.1021/np800603u Zobrazit plný text záznamu