Effect of Metformin on Potassium-adapted and Nonadapted Diabetic Rats
| Autor: | Omonkhelin J Owolabi, Eki Omogbai |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Metformin hypoglycemia potassium adapted rats non-adapted rats endocrine system diseases business.industry Potassium nutritional and metabolic diseases Pharmaceutical Science Renal function chemistry.chemical_element Urine Hypoglycemia medicine.disease Streptozotocin Metformin Endocrinology chemistry Diabetes mellitus Internal medicine medicine Pharmacology (medical) Treatment resistance business medicine.drug |
| Zdroj: | Tropical Journal of Pharmaceutical Research; Vol 11, No 5 (2012); 747-752 |
| ISSN: | 1596-9827 1596-5996 |
| DOI: | 10.4314/tjpr.v11i5.7 |
| Popis: | Purpose: To assess the effects of potassium adaptation on some biochemical parameters in diabetic rats treated with metformin.Methods: Diabetes was induced via intraperitoneal administration of streptozotocin in potassiumadapted and non-adapted rats and, then metformin (350 mg/kg) was administered orally. The following parameters were then evaluated 24 h after drug administration: urine volume, plasma glucose, plasma and urine creatinine and creatinine clearance. Lipid profiles and plasma and urine urea were also determined.Results: The blood glucose of the potassium-adapted diabetic group was not significantly reduced on treatment with metformin, compared to non-adapted diabetic rats which were significantly reduced (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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