Erythrocyte Transketolase Activity, Markers of Cardiac Dysfunction and the Diagnosis of Infantile Beriberi
| Autor: | Paul N. Newton, Khaysy Latsavong, Bandit Soumphonphakdy, Nicholas J. White, Karen Chamberlain, Bounthom Phengdy, Kongkham Sisouk, Kongsin Akkhavong, Ann Taylor, Sengmanivong Khounnorath, Khonsavanh Luangxay, Douangdao Soukaloun, Mayfong Mayxay, Sue J. Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Erythrocytes 030309 nutrition & dietetics Population RC955-962 Pediatrics and Child Health Beriberi 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Arctic medicine. Tropical medicine Medicine Humans 030212 general & internal medicine Prospective Studies education Prospective cohort study Subclinical infection 0303 health sciences education.field_of_study business.industry Public Health Environmental and Occupational Health Infant Newborn Infant Thiamine Deficiency medicine.disease 3. Good health Infectious Diseases Laos Relative risk Cohort Asymptomatic Diseases Female Transketolase Public aspects of medicine RA1-1270 business Breast feeding Research Article |
| Zdroj: | PLoS Neglected Tropical Diseases, Vol 5, Iss 2, p e969 (2011) PLoS Neglected Tropical Diseases |
| ISSN: | 1935-2735 1935-2727 |
| Popis: | Background Beriberi occurs in Vientiane, Lao PDR, among breastfed infants. Clinical disease may be the tip of an iceberg with subclinical thiamin deficiency contributing to other illnesses. Thiamin treatment could improve outcome. Methodology/Principal Findings A cohort of 778 sick infants admitted during one year without clinical evidence of beriberi were studied prospectively and erythrocyte transketolase assays (ETK) performed. Biochemical thiamin deficiency was defined both in terms of the activation coefficient (α>31%) and basal ETK activity 31% and 13.4 % basal ETK Author Summary Infantile beriberi, or clinical thiamin (vitamin B1) deficiency in infants, is a forgotten disease in Asia, where 100 years ago it was a major public health problem. Infants with this deficiency, commonly aged ∼ 2–3 months, present in cardiac failure but usually rapidly improve if given thiamin injections. It remains relatively common in Vientiane, Lao PDR (Laos), probably because of prolonged intra- and post-partum food avoidance behaviours. Clinical disease may be the tip of an iceberg with subclinical thiamin deficiency contributing to sickness in infants without overt clinical beriberi. We therefore recruited 778 sick infants admitted during one year at Mahosot Hospital, Vientiane, without clinical evidence of beriberi, and performed erythrocyte transketolase (ETK) assays. 13.4 % of infants had basal ETK |
| Databáze: | OpenAIRE |
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