The Mean Aβ Load in the Hippocampus Correlates with Duration and Severity of Dementia in Subgroups of Alzheimer Disease
| Autor: | Yongmin Kim, Grace T. Bartoo, David Nochlin, S. M. Sumi, D. Chang |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Apolipoprotein E
Pathology medicine.medical_specialty Time Factors Genotype Genetic Linkage Neuropsychological Tests Hippocampus Pathology and Forensic Medicine Central nervous system disease Cellular and Molecular Neuroscience Apolipoproteins E Degenerative disease Alzheimer Disease Internal medicine medicine Humans Dementia Age of Onset Aged Psychiatric Status Rating Scales Amyloid beta-Peptides medicine.diagnostic_test General Medicine Neuropsychological test Middle Aged medicine.disease Endocrinology Neurology Sample size determination Regression Analysis Neurology (clinical) Age of onset Alzheimer's disease Psychology |
| Zdroj: | Journal of Neuropathology and Experimental Neurology. 56:531-540 |
| ISSN: | 0022-3069 |
| DOI: | 10.1097/00005072-199705000-00009 |
| Popis: | Using image analysis techniques to quantify the percentage area covered by the immunopositive marker for amyloid beta-peptide (A beta), we examined subjects with combinations of either early-onset or late-onset Alzheimer disease (AD) and either familial Alzheimer disease (FAD) or sporadic Alzheimer disease (SAD). We measured the mean and maximum A beta loads, in the hippocampus of each subject. There were no statistically significant differences in the mean A beta load between familial and sporadic AD subjects. Although sample sizes were too small for statistical testing, subjects with the epsilon 4/epsilon 4 allele of the apolipoprotein E (ApoE) gene had higher mean A beta loads than those with the epsilon 3/epsilon 3 or epsilon 3/epsilon 4 alleles. Members of the Volga German families (recently linked to chromosome 1) all had high mean A beta loads, and one of the chromosome 14-linked subjects had the highest mean A beta load while the other had a relatively small load, but the sample was too small for statistical comparisons. The duration of dementia and neuropsychological test scores showed a statistically significant correlation with the mean A beta load in the hippocampus, but not with the maximum A beta load. This difference indicates that the mean A beta load may be a more useful feature than the maximum A beta load as an objective neuropathological measure for cognitive status. This finding may help to improve the established methods for quantitative assessment of the neuropathological changes in AD. |
| Databáze: | OpenAIRE |
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