Type IV collagen as a tumour marker for colorectal liver metastases
| Autor: | Peter Naredi, Malin Sund, Hanna Nyström, Larsolof Hafström |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Collagen Type IV Male Oncology medicine.medical_specialty Colorectal cancer Leucovorin Type IV collagen Carcinoembryonic antigen Stroma Internal medicine Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Humans Medicine neoplasms Aged Neoplasm Staging Aged 80 and over Basement membrane biology business.industry Liver Neoplasms Cancer General Medicine Middle Aged medicine.disease digestive system diseases Carcinoembryonic Antigen Tumor Burden medicine.anatomical_structure Liver metabolism Liver Cancer research biology.protein Biomarker (medicine) Female Surgery Fluorouracil Colorectal Neoplasms business |
| Zdroj: | European Journal of Surgical Oncology (EJSO). 37:611-617 |
| ISSN: | 0748-7983 |
| Popis: | About 50% of patients with primary colorectal cancer (CRC) will develop liver metastases (CLM). Currently, carcinoembryonic antigen (CEA) is the most common tumour marker for CRC and CLM. However, the sensitivity and specificity of this marker is not optimal, as almost 50% of patients have tumours that do not produce CEA. Therefore there is a need for better markers for CRC and CLM.The circulating levels of type IV collagen were measured in patients with CLM, primary CRC and in healthy controls. The expression pattern of type IV collagen was studied by immunofluorescence in CLM and normal liver tissue. The metastatic volume of CLM in the liver was estimated from CT.In CLM tissue type IV collagen is highly expressed in the areas of desmoplasia. Patients with primary CRC (Dukes' A-C) did not show any increase in circulating type IV collagen compared to healthy controls. However, patients with CLM have significantly elevated levels of circulating type IV collagen when compared to patients with primary CRC and healthy controls. The levels of type IV collagen decreased during chemotherapy and increased at the time of disease progression. The circulating levels of type IV collagen seem to reflect the tumour burden in the liver.Type IV collagen has the potential to be used as tumour associated biomarker for CLM. These results indicate the importance of interaction between cancer cells and the stroma in the tumour microenvironment. |
| Databáze: | OpenAIRE |
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