Relationship between scalp histamine levels and dandruff within an Indian population: A confirmation study using LC/MS/MS method

Autor:	Sudhahar Vijayaraghavan, Sriram Krishna Vedula, Nasrine Bourokba, TraMy Ngo, Roland Jourdain, Joan Eilstein, Ratnadeep Paul Choudhury, Nita Roy
Rok vydání:	2022
Předmět:	Scalp Tandem Mass Spectrometry Dandruff Humans Dermatology Molecular Biology Biochemistry Dermatitis Seborrheic Chromatography Liquid Histamine
Zdroj:	Experimental Dermatology. 31:814-818
ISSN:	1600-0625 0906-6705
Popis:	Dandruff is a common and challenging complaint associated with type of scalp, skin and population. Scalp seborrheic dermatitis (SD) is a more severe manifestation of dandruff associated with very severe itching and inflammation. Histamine is an interesting biomarker released in scalp affected by dandruff and SD even though the mechanism is not well understood yet. A monocentre clinical study was conducted to confirm the relationship between dandruff/SD and scalp histamine level in an Indian population. Highly sensitive liquid chromatography coupled with mass spectrometry was used for histamine quantification in scalp from samples obtained non-invasively. Results showed that scalps with dandruff and mild to moderate SD had higher histamine levels compared with healthy scalps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15fcac3fb20b9e1bca48cdd15f84987 https://doi.org/10.1111/exd.14539 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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