Drosophila Kruppel homolog 1 represses lipolysis through interaction with dFOXO
| Autor: | Kai Chang, Rachel V Thakore, Colin S. Brent, Wenjing Zheng, Hua Bai, Ying Liu, Stephanie Post, Marc Tatar, Ping Kang, Sheng Li, Galina Karashchuk, Mark Bouska |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Genetics
Zinc finger transcription factor 0303 health sciences biology Insulin medicine.medical_treatment 03 medical and health sciences chemistry.chemical_compound Insulin receptor 0302 clinical medicine chemistry Krüppel Transcription (biology) Juvenile hormone biology.protein medicine Transcription factor 030217 neurology & neurosurgery Ecdysone 030304 developmental biology |
| DOI: | 10.1101/165456 |
| Popis: | Transcriptional coordination is a vital process contributing to metabolic homeostasis. As one of the key nodes in the metabolic network, the forkhead transcription factor FOXO has been shown to interact with diverse transcription co-factors and integrate signals from multiple pathways to control metabolism, oxidative stress response, and cell cycle. Recently, insulin/FOXO signaling has been implicated in the regulation of insect development via the interaction with insect hormones, such as ecdysone and juvenile hormone. In this study, we identified an interaction between dFOXO and the zinc finger transcription factor Kruppel homolog 1 (Kr-h1), one of the key players in juvenile hormone signaling in Drosophila. We found that Kr-h1 mutants have reduced triglyceride storage, decreased insulin signaling and delayed larval development. Notably, Kr-h1 physically and genetically interacts with dFOXO in vitro and in vivo to regulate the transcriptional activation of adipose lipase brummer (bmm). The transcriptional co-regulation by Kr-h1 and dFOXO may represent a broad mechanism by which Kruppel-like factors integrate with insulin signaling to maintain metabolic homeostasis and coordinate organism growth. |
| Databáze: | OpenAIRE |
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