Topiramate treatment in Wistar rats during childhood induces sex-specific vascular dysfunction in adulthood
| Autor: | Camila B. Vidigal, Kawane F. Moura, Tiago J. Costa, Lorena I. Borges, Pedro M.M. Figaro, Ingrid C. Pinto, Fábio G. de Andrade, Daniela C.C. Gerardin, Rubia Casagrande, Rita C. Tostes, Maria do Carmo Franco, Graziela S. Ceravolo |
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| Rok vydání: | 2021 |
| Předmět: |
Male
NADPH Oxidases General Medicine General Biochemistry Genetics and Molecular Biology Rats Sex Factors Gene Expression Regulation Prostaglandin-Endoperoxide Synthases Topiramate NADPH Oxidase 2 Animals Anticonvulsants Female Vascular Diseases General Pharmacology Toxicology and Pharmaceutics Rats Wistar Aorta |
| Zdroj: | Life sciences. 288 |
| ISSN: | 1879-0631 |
| Popis: | The present study determined whether treatment during childhood with topiramate (TPM), a new generation antiepileptic drug, results in altered aortic reactivity in adult male and female rats. We also sought to understand the role of endothelium-derived contractile factors in TPM-induced vascular dysfunction. Male and female Wistar rats were treated with TPM (41 mg/kg/day) or water (TPM vehicle) by gavage during childhood (postnatal day, 16-28). In adulthood, thoracic aorta reactivity to phenylephrine (phenyl), as well as aortic thickness and expression of cyclooxygenases (COX-1 and COX-2), NOX2, and p47 |
| Databáze: | OpenAIRE |
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