Significance of nm23 immunoexpression in the prognosis of renal cell carcinoma
| Autor: | Hakan Vuruşkan, E Akar, Gülaydan Filiz, Berna Aytaç, Saduman Balaban Adim |
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| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı., Filiz, Gülaydan, Adım, Şaduman Balaban, Aytaç, Berna, Akar, Eylem, Vuruşkan, Hakan, AAH-9746-2021 |
| Rok vydání: | 2010 |
| Předmět: |
Stage
Male Pathology Unclassified drug Expression Cancer staging Biochemistry Metastasis Immunoenzyme Techniques Immunoreactivity Renal cell carcinoma Medicine Tumor suppressor gene Stage (cooking) Lymph node Fuhrman nuclear grade Cancer Survival time Aged 80 and over Kidney carcinoma biology General Medicine Middle Aged NM23 Nucleoside Diphosphate Kinases Cancer classification Prognosis Immunohistochemistry Kidney Neoplasms Non metastatic gene 23 protein Survival Rate medicine.anatomical_structure Lymphatic Metastasis Female Antibody NM23 Human Adult medicine.medical_specialty Research & experimental medicine Major clinical study Article Association Biomarkers Tumor Humans Medicine research & experimental Human tissue Gene Carcinoma Renal Cell Aged Retrospective Studies Lymph node metastasis Pharmacology & pharmacy business.industry Protein Protein localization Biochemistry (medical) Follow up Cell Biology medicine.disease Tumor suppressor protein Metastasis Suppressor Gene biology.protein Protein expression business Nucleoside-Diphosphate Kinase Suppressors Prunes Controlled study |
| Zdroj: | The Journal of international medical research. 38(2) |
| ISSN: | 0300-0605 |
| Popis: | Non-metastatic gene 23 (nm23) is a metastasis suppressor gene that is expressed in all tissues and decreased nm23 expression may be linked to poor prognosis. By immunohistochemical staining of nm23 protein antibodies this study examined the prognostic value of nm23 protein expression in 54 renal cell carcinoma (RCC) patients and analysed its relationship with tumour, node, metastases (TNM) surgical stage, Fuhrman nuclear grade, lymph node involvement and survival. Of the 54 RCC cases studied, 11 (20.4%) showed positive lymph node involvement while 43 (79.6%) were lymph node negative. There was no difference in nm23 protein expression between cases with and without lymph node involvement. In addition, nm23 protein expression was not related to TNM stage, Fuhrman nuclear grade or survival. More extensive studies are required to understand the effect of nm23 protein expression on the biological behaviour of RCC. |
| Databáze: | OpenAIRE |
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