Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-κB Pathway
| Autor: | Xiang-hua Zhang, Xiang-Sheng Zhang, Yi-Peng Dong, Da-Yong Xia, Cheng-Jun Wang, Jing Zhang, Lei Peng, Cang Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
subarachnoid hemorrhage Inflammation Pharmacology HMGB1 Neuroprotection Proinflammatory cytokine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Berberine Sirtuin 1 berberine medicine Pharmacology (medical) Original Research Microglia biology Chemistry lcsh:RM1-950 Coptis chinensis biology.organism_classification 030104 developmental biology medicine.anatomical_structure lcsh:Therapeutics. Pharmacology inflammation 030220 oncology & carcinogenesis biology.protein medicine.symptom |
| Zdroj: | Frontiers in Pharmacology Frontiers in Pharmacology, Vol 11 (2020) |
| ISSN: | 1663-9812 |
| Popis: | Excessive cerebral inflammation plays a key role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Berberine, an isoquinoline alkaloid isolated from Chinese herb Coptis chinensis, possesses anti-inflammatory, and neuroprotective effects. Here we evaluated the beneficial effects of berberine against SAH-induced inflammatory response and the subsequent brain injury. Our data showed that berberine treatment significantly inhibited microglia activation and proinflammatory cytokines release. Concomitant with suppressed cerebral inflammation, berberine mitigated the subsequent brain injury as demonstrated by improved neurological behavior, reduced brain edema, and decreased neural apoptosis. Moreover, berberine significantly inhibited high mobile group box 1 (HMGB1)/nuclear factor-κB (Nf-κB)-dependent pathway and enhanced sirtuin 1 (SIRT1) expression after SAH. Treatment with ex527, a selective SIRT1 inhibitor, reversed berberine-induced SIRT1 activation and inhibitory effects on HMGB1/Nf-κB activation. In addition, ex527 pretreatment abated the anti-inflammatory and neuroprotective effects of berberine on SAH. Taken together, these findings suggest that berberine provides beneficial effects against SAH-triggered cerebral inflammation by inhibiting HMGB1/Nf-κB pathway, which may be modulated by SIRT1 activation. |
| Databáze: | OpenAIRE |
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