miRNA profiles change during grass pollen immunotherapy irrespective of clinical outcome

Autor:	Krzysztof Specjalski, Agnieszka Maciejewska, Jan Romantowski, Ryszard Pawłowski, Ewa Jassem, Marek Niedoszytko
Rok vydání:	2022
Předmět:	Sublingual Immunotherapy Injections Subcutaneous Immunology Rhinitis Allergic Seasonal Allergens Poaceae Rhinitis Allergic MicroRNAs Oncology Desensitization Immunologic Humans Immunologic Factors Pollen Immunology and Allergy
Zdroj:	Immunotherapy. 14:433-444
ISSN:	1750-7448 1750-743X
Popis:	Background: Subcutaneous immunotherapy (SCIT) is widely used in the treatment of allergic rhinitis (AR). This study aimed to determine the expression of 48 miRNAs in patients with AR undergoing grass pollen SCIT and investigate relations with clinical outcomes. Methodology: Expression of selected miRNAs was determined using RT-PCR in the full blood of 16 patients with AR and seven healthy controls. Results: miR-136, miR-208 and miR-190 were upregulated in the AR group. After 6 months of SCIT, significant downregulation of some proinflammatory miRNAs and upregulation of several miRNAs regulating Th1/Th2 balance were found. No differences were found between good and poor responders. Conclusion: miRNAs may play a regulatory role in SCIT, leading to tolerance induction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b159c82d327d0ee872fbfb478fae4ec6 https://doi.org/10.2217/imt-2021-0217 Zobrazit plný text záznamu