Inhibition of the Accumulation of Uremic Toxins in the Blood and Their Precursors in the Feces after Oral Administration of Lebenin®, a Lactic Acid Bacteria Preparation, to Uremic Patients Undergoing Hemodialysis
| Autor: | Takeshi Satoh, Yasuhiro Koga, Sadaaki Sawamura, Yuji Aiba, Nobuyuki Suzuki, Miho Hida |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_treatment Administration Oral Capsules Indican Pharmacology medicine.disease_cause Microbiology Bacteria Anaerobic Cresols Feces chemistry.chemical_compound Phenols Renal Dialysis Oral administration Enterococcus faecalis medicine Humans Uremia Bifidobacterium Phenol biology business.industry Toxin General Medicine Middle Aged biology.organism_classification Lactic acid Bacteria Aerobic Lactobacillus acidophilus chemistry Nephrology Female Hemodialysis business Bacteria |
| Zdroj: | Nephron. 74:349-355 |
| ISSN: | 1423-0186 0028-2766 |
| DOI: | 10.1159/000189334 |
| Popis: | The plasma levels of phenol, p-cresol, and indican are markedly increased in uremic patients, and cannot be efficiently reduced by hemodialysis. Such uremic toxins, which are produced in the intestine as bacterial putrefactive metabolites, accumulate to a great degree in the feces of hemodialysis patients. Oral administration of Lebenin, a preparation consisting of antibiotic-resistant lactic acid bacteria, reduced the levels of fecal putrefactive metabolites to levels comparable with those of healthy subjects. Moreover, the plasma level of indican also significantly decreased in these Lebenin-treated patients. An analysis of the fecal microflora revealed that a disturbed composition of the microflora characterized by an overgrowth of aerobic bacteria is restored to normal by oral administration of Lebenin in hemodialysis patients. These results thus demonstrate that oral administration of lactic acid bacteria in uremic patients is effective in reducing the levels of uremic toxins, especially that of indican, in the blood by inhibiting bacterial production by means of correcting the intestinal microflora. |
| Databáze: | OpenAIRE |
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