PP181. The role of the JAK-STAT pathways and SOCS in preeclampsia
| Autor: | A.C.A. Ventura, Nelson Sass, J.M. Garcia, Diego Gomes Ferreira, Wittaya Chaiwangyen, Francisco Lazaro Pereira de Sousa, Udo R. Markert, L.T. Cavalhieri, Maria R.S. Mesquita, F.T. Aires, S. Ospina Prieto |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pregnancy business.industry Insulin medicine.medical_treatment Obstetrics and Gynecology medicine.disease Obesity Preeclampsia chemistry.chemical_compound Endocrinology Insulin resistance chemistry Internal medicine Statistical significance Internal Medicine Medicine Gestation Uric acid business |
| Zdroj: | Pregnancy hypertension. 2(3) |
| ISSN: | 2210-7789 |
| Popis: | decreases insulin sensitivity and is associated with obesity. Recent data indicates that subclinical endotoxemia is associated with inflammation in obese women in late pregnancy. Objectives: The objective of this study was to quantify circulating endotoxin across pregnancy in lean and obese women, and assess the relationship between endotoxin and markers of inflammation and insulin sensitivity. Methods: Endotoxin was measured in sterile maternal EDTA plasma samples from 24 lean pregnant women (BMI = 22.4 ± 1.9 kg/m) and 45 obese pregnant women (BMI= 32.6 ± 2.1 kg/m), and 6 non-pregnant women. Samples were collected at 10.5 ± 3.1, 21.3 ± 4.6 and 35.2 ± 2.1 weeks gestation. Endotoxin was quantified using the PyroGene Recombinant Factor C endotoxin detection assay from LONZA, inter-assay variability |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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